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      Effects of Calcium Hopantenate on the Hypothalamic-Pituitary-Thyroid Axis in Rats

      ,

      Hormone Research in Paediatrics

      S. Karger AG

      Calcium hopantenate, Thyrotropin-releasing hormone, Thyrotropin, GABA

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          Abstract

          Effects of calcium hopantenate (HOPA) on the hypothalamic pituitary-thyroid axis in rats were studied. Basal plasma thyrotropin (TSH) levels significantly decreased from 277 ± 24 to 167 ± 24 ng/ml (p < 0.01) at 20 min after HOPA administration. In the bicuculline-pretreated rats, the inhibitory effect of HOPA on TSH release was corrected. The plasma immunoreactive thyrotropin-releasing hormone (TRH) and TSH responses to cold were significantly inhibited after HOPA administration. The plasma TSH response to TRH was also significantly inhibited by HOPA. The plasma thyroxine and 3,3’,5-triiodothyronine levels did not change after HOPA administration. Findings suggest that HOPA acts both on the hypothalamus and pituitary gland, inhibiting TRH and TSH release.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1983
          1983
          26 November 2008
          : 18
          : 4
          : 210-214
          Affiliations
          Fourth Department of Internal Medicine, Aichi Medical University, Nagakute, Aichi, Japan
          Article
          179797 Horm Res 1983;18:210–214
          10.1159/000179797
          6416983
          © 1983 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 5
          Categories
          Original Paper

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