31
views
0
recommends
+1 Recommend
1 collections
    0
    shares

      To submit your manuscript, please click here

      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Geographical Disparities in Pooled Stroke Incidence and Case Fatality in Mainland China, Hong Kong, and Macao: Protocol for a Systematic Review and Meta-analysis

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Background

          Geographical variations in stroke incidence and case fatality in China have been reported. Nonetheless, pooled estimates in major Chinese regions are unknown.

          Objective

          This systematic review and meta-analysis aims to investigate pooled estimates of incidence and short-term case fatality of stroke in Mainland China, Hong Kong, and Macao.

          Methods

          Longitudinal studies published in English and indexed in PubMed/MEDLINE, Embase, CINAHL, and Web of Science, or in Chinese and indexed in SinoMed and CQVIP will be targeted. Articles reporting on adults living in China who experience first-ever stroke or die within 1 year from newly onset stroke will be included. The 95% confidence intervals of the event will be estimated using the exact method based on the Poisson distribution. The log incidence rates together with their corresponding log standard errors will be meta-analyzed using DerSimonian and Laird random effects models. Pooled case fatality rates will also be estimated using a random effect model. Time trends in pooled age-standardized stroke incidence and case fatality will be estimated. The heterogeneity of the included studies will be measured using the I 2 statistic and meta-regressions will be run to analyze the effect of reported covariates on found heterogeneity. Risk of bias will be examined using the Newcastle-Ottawa Scale. Publication bias will be tested using funnel plots and Egger tests. Sensitivity analysis will be run by risk of bias.

          Results

          This study was funded and registered in 2020. The systematic searches, study selections, and quality assessments were completed in July 2021. Data extraction and analysis and manuscript writing are scheduled to be completed by December 2021.

          Conclusions

          This will be the first study to provide regional differences in pooled estimates of stroke incidence with case fatality in Mainland China, Hong Kong, and Macao. This study will assist in addressing inequalities in stroke care across China.

          Trial Registration

          PROSPERO International Prospective Register of Systematic Reviews CRD42020170724; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=170724

          International Registered Report Identifier (IRRID)

          PRR1-10.2196/32566

          Related collections

          Most cited references30

          • Record: found
          • Abstract: found
          • Article: not found

          Measuring inconsistency in meta-analyses.

            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            Meta-analysis in clinical trials

              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Prevalence, Incidence, and Mortality of Stroke in China: Results from a Nationwide Population-Based Survey of 480 687 Adults.

              China bears the biggest stroke burden in the world. However, little is known about the current prevalence, incidence, and mortality of stroke at the national level, and the trend in the past 30 years.
                Bookmark

                Author and article information

                Contributors
                Journal
                JMIR Res Protoc
                JMIR Res Protoc
                ResProt
                JMIR Research Protocols
                JMIR Publications (Toronto, Canada )
                1929-0748
                January 2022
                18 January 2022
                : 11
                : 1
                : e32566
                Affiliations
                [1 ] John Richards Centre for Rural Ageing Research La Trobe Rural Health School La Trobe University Wodonga Australia
                [2 ] Department of Rehabilitation Medicine The Second Affiliated Hospital of Kunming Medical University Kunming China
                [3 ] Department of Health Care Peking Union Medical College Hospital Beijing China
                [4 ] Rural Department of Community Health La Trobe Rural Health School La Trobe University Bendigo Australia
                [5 ] The Peter Doherty Institute for Infection and Immunity Melbourne Australia
                Author notes
                Corresponding Author: Fan He a.f.he@ 123456outlook.com
                Author information
                https://orcid.org/0000-0001-5696-0631
                https://orcid.org/0000-0003-4482-4936
                https://orcid.org/0000-0001-6951-2846
                https://orcid.org/0000-0002-0814-192X
                https://orcid.org/0000-0002-7698-5091
                Article
                v11i1e32566
                10.2196/32566
                8808348
                35040797
                10535ba0-55c9-4f0f-af74-26a6de5b277b
                ©Fan He, Irene Blackberry, Liqing Yao, Haiyan Xie, George Mnatzaganian. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 18.01.2022.

                This is an open-access article distributed under the terms of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Research Protocols, is properly cited. The complete bibliographic information, a link to the original publication on https://www.researchprotocols.org, as well as this copyright and license information must be included.

                History
                : 2 August 2021
                : 4 October 2021
                : 9 October 2021
                : 12 October 2021
                Categories
                Protocol
                Protocol

                case fatality,hong kong,incidence,mainland china,macao,meta-analysis,stroke,systematic review,stroke incidence,mortality rates,epidemiology

                Comments

                Comment on this article