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      Dysregulation of the dopamine system in the pathophysiology of schizophrenia and depression

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      , Ph.D.
      Nature reviews. Neuroscience

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          Abstract

          The dopamine (DA) system is unique among the brain’s modulatory systems in that it has discrete projections to specific brain regions involved in motor behaviour, cognition and emotion. DA neurons exhibit several activity patterns — including tonic and phasic firing — that are determined by a combination of endogenous pacemaker conductances and regulation by multiple afferent systems. Emerging evidence suggests that disruptions within these regulatory systems may underlie the pathophysiology of several psychiatric disorders including schizophrenia and depression.

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          Contributors
          Journal
          100962781
          22270
          Nat Rev Neurosci
          Nat. Rev. Neurosci.
          Nature reviews. Neuroscience
          1471-003X
          1471-0048
          14 December 2016
          03 June 2016
          August 2016
          01 February 2017
          : 17
          : 8
          : 524-532
          Affiliations
          Departments of Neuroscience, Psychiatry and Psychology
          Author notes
          Address: Department of Neuroscience, A210 Langley Hall, University of Pittsburgh, Pittsburgh, PA 15260, USA, Tel: +1 412 624 4609, FAX: +1 412 624 9198, GraceAA@ 123456pitt.edu
          Article
          PMC5166560 PMC5166560 5166560 nihpa835949
          10.1038/nrn.2016.57
          5166560
          27256556
          10605cb3-1aa0-4d72-9dfa-bc6b28137e22
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