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      Incidence and Regression of Actinic Keratoses in Organ Transplant Recipients.

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          Abstract

          Actinic keratoses (AKs) are highly dynamic lesions and AK activity has been shown to be associated with squamous cell carcinoma (SCC). We sought to explore risk factors which may affect the 12-month turnover of AKs in organ transplant recipients (OTRs). The number of incident AKs, regressed AKs and net change in AK counts were calculated. Negative binomial regression and Poisson regression models were used to estimate rate ratios (RR) for these 3 outcomes. Among 150 renal and 89 liver OTRs, those who spent > 50% of a typical weekday in the sun had a lower rate of AK regression than those who spent minimal time in the sun during a typical weekday. Age, parents' country of origin, hair colour, skin cancer history and recent AK treatment were all significantly associated with AK turnover. Clinically, these risk factors may be used to monitor OTRs at increased risk of SCC.

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          Author and article information

          Journal
          Acta Derm Venereol
          Acta dermato-venereologica
          Medical Journals Sweden AB
          1651-2057
          0001-5555
          Jan 12 2018
          : 98
          : 1
          Affiliations
          [1 ] Cancer and Population Studies Group, QIMR Berghofer Medical Research Institute, Locked Bag 2000 Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia. E-mail: zainabjiyad@doctors.org.uk.
          Article
          10.2340/00015555-2783
          28853496
          10788abe-c536-4c21-bf25-5d6d7b864457
          History

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