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Cerebellar pilocytic astrocytomas with spontaneous intratumoral hemorrhage in the elderly : A case report and review of the literature

, MD, , MD, , MD, , MD

Medicine

Wolters Kluwer Health

cerebellar, elderly, intratumoral hemorrhage, pilocytic astrocytomas

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      Abstract

      Rationale:

      Pilocytic astrocytoma (PA) is the most common pediatric central nervous system glial tumor. Adult occurrence is rare, especially in elderly adults. How to manage the pilocytic astrocytoma with spontaneous intratumoral hemorrhage in the elderly is still unfamiliar with clinician.

      Patient concerns:

      Reports of tumors with intratumoral hemorrhage in elderly adults are extremely rare. We report a case of a 62-year-old male diagnosed with cerebellar pilocytic astrocytomas with spontaneous intratumoral hemorrhage. Informed consent was obtained from the patient.

      Diagnoses:

      Histological examination of the specimens revealed pilocytic astrocytomas, including a hemorrhagic portion.

      Interventions:

      The patient underwent the radical resections of tumour and was given the regular follow-up.

      Outcomes:

      12 months later, he recovered without evidence of disease.

      Lessons:

      Cerebellar pilocytic astrocytomas associated with hemorrhages occur over the age of 60 is extremely rare. Removing the tumor and hematoma completely is the best treatment options. Long term follow-up is very necessary for this tumor.

      Related collections

      Most cited references 20

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      Pilocytic astrocytoma: a retrospective study of 32 cases.

      Pilocytic astrocytoma (PA) is a neoplasia which is considered as a grade I astrocytoma by the World Health Organization (WHO). Its most common location is the cerebellum and it develops during the first two decades of life. Prognosis is mostly excellent if gross-total resection can be achieved, with 10-year survival rates of up to 95%. In rare cases, however, the patient has a bad outcome. Our aims were to retrospectively describe the clinicopathological features of 32 PAs, and identify factors that may be associated with aggressive behavior. The study included 21 males and 11 females with a median age of 10.5 years. Tumors demonstrated predilection for infratentorial location (74.9%), especially the cerebellum (59.3%), followed by cerebral ventricles (15.6%), supratentorial location (12.5%) and optic pathway (3.12%). Gross total resection was achieved in 14 tumors only. On histopathology, moderate cellularity (68.7%), microcystic changes (71.9%), Rosenthal fibers (62.5%) and eosinophilic granular bodies (53.2%) were present in the majority of cases. Atypia was present in 62.5% of cases, while endothelial proliferation and necrosis was noted in 3 and 2 cases, respectively. Median follow-up for all patients was 24 months. Four patients died in the postoperative period, one of whom was 62-year-old men and two others had brainstem location or invasion. Recurrence was observed in a 56-year-old patient whom first tumor was locally invasive. The patient died after the second surgery and anaplastic features was found in the recurrent tumor without previous radiotherapy. PA is a benign tumor, but some clinicopathological factors, such as partial resection, brainstem location and adult age have a worse prognosis.
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        New editorial team for neuro-oncology.

         Patrick Wen (2014)
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          Cerebellar pilocytic astrocytoma presenting with intratumor bleeding, subarachnoid hemorrhage, and subdural hematoma.

          Massive intracranial hemorrhage is a very rare initial presentation of cerebellar pilocytic astrocytomas. There are no reports in the medical literature on a cerebellar pilocytic astrocytoma presenting with intratumor bleeding (ITB), subarachnoid hemorrhage (SAH), and subdural hematoma (SDH). A 15-month-old boy presented with lethargy and nausea to our hospital. Magnetic resonance imaging showed a mass with ITB at the left cerebellar hemisphere in addition to SDH in the posterior fossa and SAH at the interpeduncular cistern. The patient underwent emergency surgery. On incising the dura, we found SDH, the tumor was visible at the cerebellar cortex, and near total removal followed. Microscopic examination of tissue sections revealed a pilocytic astrocytoma. The authors' case is the first report with a presentation including ITB, SAH, and SDH. The presumed mechanism of the SAH and SDH was leaking of the ITB into subarachnoid and subdural spaces.
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            Author and article information

            Affiliations
            Department of Neurosurgery, Xuzhou Medical University Affiliated Hospital of Lianyungang, Lianyungang, China.
            Author notes
            []Correspondence: Hui Shi, Department of Neurosurgery, Xuzhou Medical University Affiliated Hospital of Lianyungang, Lianyungang, No. 182, Tongguan Road (North), Haizhou District, Lianyungang 222000, Jiangsu, China (e-mail: 15949043694@ 123456163.com ).
            Journal
            Medicine (Baltimore)
            Medicine (Baltimore)
            MEDI
            Medicine
            Wolters Kluwer Health
            0025-7974
            1536-5964
            August 2018
            03 August 2018
            : 97
            : 31
            30075500
            6081062
            MD-D-18-01941
            10.1097/MD.0000000000011329
            11329
            (Editor)
            Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc.

            This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0

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