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      Seroprevalence of hepatitis B virus among hemodialysis patients in Bushehr province, southern Iran : HBV seroprevalence in hemodialysis patients

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          Abstract

          Background

          Hepatitis B virus (HBV) infection is still reported from adult hemodialysis units.

          Objectives

          To determine the prevalence of anti-HBs antibody in hemodialysis patients and the correlation between levels of anti-HBs antibody with other factors.

          Patients and Methods

          HBsAg, anti-HBs and anti-HBc antibodies level in 119 hemodialysis patients were evaluated by enzyme-linked immunosorbent assay.

          Results

          Seroconversion (anti-HBs antibody >10 IU/L) was found in 22 patients. Minimum protective antibody level was found in patients aged ≥60 years. Statistically significant correlation was not found between anti-HBs antibody and gender. Ten (8.4%) patients had abnormal ALT and/or AST. Prevalence of HBsAg, anti-HBc antibody, HBeAg and anti-HBe antibody were found in 8 (6.72%), 24 (25.16%), 2 (1.68%) and 3 (2.52%) patients, respectively.

          Conclusions

          Periodic assessment of anti-HBs antibody level is strongly recommended in patients undergoing hemodialysis.

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          Most cited references35

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          Hepatitis B virus infection.

          Yun-Fan Liaw, Chia-Ming Chu (2009)
          Since the introduction of the hepatitis B vaccine and other preventive measures, the worldwide prevalence of hepatitis B infection has fallen. However, chronic infection remains a challenging global health problem, with more than 350 million people chronically infected and at risk of hepatic decompensation, cirrhosis, and hepatocellular carcinoma. An improved understanding of hepatitis B virology, immunology, and the natural course of chronic infection, has identified hepatitis B virus replication as the key driver of immune-mediated liver injury and disease progression. The approval of potent oral antiviral agents has revolutionised hepatitis B treatment since 1998. Conventional and pegylated interferon alfa and nucleoside and nucleotide analogues are widely authorised treatments, and monotherapy with these drugs greatly suppresses virus replication, reduces hepatitis activity, and halts disease progression. However, hepatitis B virus is rarely eliminated, and drug resistance is a major drawback during long term therapy. The development of new drugs and strategies is needed to improve treatment outcomes.
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            Chronic hepatitis B.

            Anna Lok, Brian McMahon (2007)
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              Review article: Hepatitis B and dialysis.

              Katherine Barraclough, David Johnson, Matthew Edey (2010)
              The incidence of hepatitis B virus (HBV) infection in dialysis populations has declined over recent decades, largely because of improvements in infection control and widespread implementation of HBV vaccination. Regardless, outbreaks of infection continue to occur in dialysis units, and prevalence rates remain unacceptably high. For a variety of reasons, dialysis patients are at increased risk of acquiring HBV. They also demonstrate different disease manifestations compared with healthy individuals and are more likely to progress to chronic carriage. This paper will review the epidemiology, modes of transmission and diagnosis of HBV in this population. Prevention and treatment will be discussed, with a specific focus on strategies to improve vaccination response, new therapeutic options and selection of patients for therapy.
              Article 0 comments Cited 51 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Hepat Mon
                Journal ID (publisher-id): Kowsar
                Title: Hepatitis Monthly
                Publisher: Kowsar
                ISSN (Print): 1735-143X
                ISSN (Electronic): 1735-3408
                Publication date (Print): 01 March 2011
                Publication date (Electronic): 01 March 2011
                Volume: 11
                Issue: 3
                Pages: 200-202
                Affiliations
                [1 ]Gastroenterohepatology Research Center, Nemazee Hospital,Shiraz University of Medical Sciences, Shiraz, IR Iran
                [2 ]Department of Internal Medicine, Bushehr University of Medical Sciences, Bushehr, IR Iran
                [3 ]Stem Cell and Transgenic Technology Research Center,Shiraz University of Medical Sciences, Shiraz, IR Iran
                Author notes
                * Corresponding author at: Davood Mehrabani, Assistant Professor of Pathology, Stem Cell and Transgenic Technology Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran. Tel.: +98-7116474263, Fax: +98-7116474263, E-mail: mehrabad@ 123456sums.ac.ir
                Article
                PMC ID: 3206679
                PubMed ID: 22087144
                SO-VID: 10943ff9-1e2a-4241-9b63-c8016d253eb7
                Copyright © Copyright © 2011, Kowsar M.P. Co.
                License:

                This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 12 October 2010
                Date accepted : 09 November 2010
                Date revision received : 06 November 2010
                Categories
                Subject: Original Article

                ScienceOpen disciplines: Infectious disease & Microbiology
                Keywords: prevalence,iran,hepatitis b virus,anti-hbs antibody,hemodialysis
                Data availability:
                ScienceOpen disciplines: Infectious disease & Microbiology
                Keywords: prevalence, iran, hepatitis b virus, anti-hbs antibody, hemodialysis

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