How Do the Accrual Pattern and Follow‐Up Duration Affect the Hazard Ratio Estimate When the Proportional Hazards Assumption Is Violated?

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Abstract

In randomized clinical trials, the magnitude of the treatment effect is often reported using the hazard ratio (HR) even when the proportional hazards (PH) assumption is not met. Conducting numerical studies, this commentary illustrates how/why the HR estimate via the standard Cox's procedure is difficult to interpret even as an “average” treatment effect for non‐PH cases.

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Author and article information

Contributors

Hajime Uno:

ORCID: https://orcid.org/0000-0003-0622-8471

huno@jimmy.harvard.edu

Journal

Journal ID (nlm-ta): Oncologist

Journal ID (iso-abbrev): Oncologist

Journal ID (doi): 10.1002/(ISSN)1549-490X

Journal ID (publisher-id): The Oncologist

Journal ID (pmc): oncologist

Journal ID (hwp): theoncologist

Title: The Oncologist

Publisher: John Wiley & Sons, Inc. (Hoboken, USA )

ISSN (Print): 1083-7159

ISSN (Electronic): 1549-490X

Publication date (Electronic): 10 September 2018

Publication date (Print): July 2019

Volume: 24

Issue: 7 ( doiID: 10.1002/onco.v24.7 )

Pages: 867-871

Affiliations

[ ^a ] Department of Clinical Medicine (Biostatistics), Kitasato University Graduate School of Pharmaceutical Sciences , Tokyo, Japan

[ ^b ] Department of Medical Oncology, Dana‐Farber Cancer Institute , Boston, Massachusetts, USA

[ ^c ] Department of Biostatistics and Computational Biology, Dana‐Farber Cancer Institute , Boston, Massachusetts, USA

Author notes

Disclosures of potential conflicts of interest may be found at the end of this article.

[*] [* ]Correspondence: Hajime Uno, Ph.D., Dana‐Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, USA. Telephone: 1‐617‐632‐6893; e‐mail: huno@ 123456jimmy.harvard.edu

Author information

Hajime Uno https://orcid.org/0000-0003-0622-8471

Article

Accession ID: PMC6656438 Pmcid ID: PMC6656438 Pmc-uid ID: 6656438 Publisher ID: ONCO12694

DOI: 10.1634/theoncologist.2018-0141

PMC ID: 6656438

PubMed ID: 30201741

SO-VID: 109b590f-c658-439a-abba-2442a9145dcb

History

Date received : 06 March 2018

Date accepted : 25 June 2018

Page count

Pages: 5

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