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      Quantitative MRI of Kidneys in Renal Disease

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          Abstract

          Purpose

          To evaluate the reproducibility and utility of quantitative magnetic resonance imaging (MRI) sequences for the assessment of kidneys in young adults with normal renal function (eGFR ranged from 90 to 130mL/min/1.73m 2) and patients with early renal disease (autosomal dominant polycystic kidney disease).

          Materials and Methods

          This prospective case-control study was performed on ten normal young adults (18–30 years old) and ten age and sex matched patients with early renal parenchymal disease (Autosomal Dominant Polycystic Kidney Disease). All subjects underwent a comprehensive kidney MRI protocol, including qualitative imaging: T1w, T2w, FIESTA, and quantitative imaging: 2D cine phase contrast of the renal arteries, and parenchymal diffusion weighted imaging (DWI), magnetization transfer imaging (MTI), blood oxygen level dependent (BOLD) imaging, and magnetic resonance elastography (MRE). The normal controls were imaged on two separate occasions ≥24 hours apart (range 24 to 210hrs) to assess reproducibility of the measurements.

          Results

          Quantitative MR imaging sequences were found to be reproducible. The mean±SD absolute percent difference between quantitative parameters measured ≥24 hours apart were: MTI-derived ratio = 4.5±3.6%, DWI-derived apparent diffusion coefficient (ADC) = 6.5±3.4%, BOLD-derived R2* = 7.4±5.9%, and MRE-derived tissue stiffness = 7.6±3.3%. Compared with controls, the ADPKD patient’s non-cystic renal parenchyma (NCRP) had statistically significant differences with regard to quantitative parenchymal measures: lower MTI percent ratios (16.3±4.4 vs. 23.8±1.2, p<0.05), higher ADCs (2.46±0.20 vs. 2.18±0.10 × 10 −3 mm 2/sec, p<0.05), lower R2*s (14.9±1.7 vs. 18.1±1.6 sec −1, p<0.05), and lower tissue stiffness (3.2±0.3 vs. 3.8±0.5 kPa, p<0.05).

          Conclusion

          Excellent reproducibility of the quantitative measurements was obtained in all cases. Significantly different quantitative MR parenchymal measurement parameters between ADPKD patients and normal controls were obtained by MT, DWI, BOLD, and MRE indicating the potential for detecting and following renal disease at an earlier stage than the conventional qualitative imaging techniques.

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          Author and article information

          Journal
          101674571
          44756
          Abdom Radiol (NY)
          Abdom Radiol (NY)
          Abdominal radiology (New York)
          2366-004X
          2366-0058
          7 July 2017
          March 2018
          01 March 2019
          : 43
          : 3
          : 629-638
          Affiliations
          [* ]Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN
          []Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, Rochester, MN
          Author notes
          Corresponding Author: Timothy L. Kline, 200 First St SW, Rochester, MN 55905, 507–538–3945, kline.timothy@ 123456mayo.edu
          Article
          PMC5745297 PMC5745297 5745297 nihpa889116
          10.1007/s00261-017-1236-y
          5745297
          28660330
          109c9a4f-0833-4669-b732-50cc89e09590
          History
          Categories
          Article

          total kidney volume,segmentation,quantitative magnetic resonance imaging,magnetic resonance imaging,Autosomal dominant polycystic kidney disease

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