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      Carbazoles and coumarins from Clausena harmandiana stimulate glucose uptake in L6 myotubes.

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          Abstract

          Two carbazoles (compounds 1 and 2) and one coumarin (compound 8) from Clausena harmandiana exhibited significant glucose uptake activity in L6 myotubes in a time and dose dependent manner. In addition, compounds 2 and 8 were inhibited by p38 mitogen-activated protein kinases and phosphatidylinositol 3-kinases, respectively.

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          Author and article information

          Journal
          Diabetes Res. Clin. Pract.
          Diabetes research and clinical practice
          Elsevier BV
          1872-8227
          0168-8227
          Dec 2010
          : 90
          : 3
          Affiliations
          [1 ] Drug Delivery System Excellence Center, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Songkhla 90110, Thailand.
          Article
          S0168-8227(10)00450-X
          10.1016/j.diabres.2010.09.005
          20888659
          10b00f9c-0161-48aa-95ea-c3adfefef9bc
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