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      The role of leptin in health and disease

      1 , 1
      Temperature
      Informa UK Limited

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          Abstract

          Leptin is a master regulator of energy balance and body adiposity. Additionally, leptin exerts important control on glucose homeostasis, thermogenesis, autonomic nervous system and neuroendocrine axes. In metabolic diseases, such as obesity and diabetes mellitus, leptin signaling may be compromised, indicating the important role of this hormone in the etiology and pathophysiological manifestations of these conditions. In the present manuscript, we reviewed important concepts of leptin signaling, as well as about the effects of leptin on several biologic functions. We also discussed the possible therapeutic use of leptin administration and how our current obesogenic environment contributes to the development of leptin resistance. Our objective was to provide a comprehensive and state-of-the-art review about the importance of leptin to maintain the homeostasis and during pathological conditions.

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          Author and article information

          Journal
          Temperature
          Temperature
          Informa UK Limited
          2332-8940
          2332-8959
          August 04 2017
          July 03 2017
          May 26 2017
          July 03 2017
          : 4
          : 3
          : 258-291
          Affiliations
          [1 ] Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil
          Article
          10.1080/23328940.2017.1327003
          5605162
          28944270
          10b14784-bfb7-4e68-87e2-612435217e2e
          © 2017
          History

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