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      The Mode of ATP-Induced Vasoconstriction in the Canine Internal Carotid Artery

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          The mode of the ATP-induced vasoconstriction in the internal carotid artery was studied from the physiological and pharmacological points of view. ATP caused dose-dependent vasoconstrictions in the canine internal carotid artery. The ATP-induced vasoconstriction was not affected by pretreatment with phenoxybenzamine, propranolol, atropine, cyproheptadine, or tetrodotoxin. Verapamil suppressed the contractile response. ATP produced no vasoconstriction in a calcium-free Krebs solution containing 1 m M EGTA nor augmentation of Ca<sup>2+</sup>-induced contraction in potassium-depolarized tissues. These results suggest that an increase of potential-dependent Ca<sup>2+</sup> influx into the arterial smooth muscle may play a major role in the ATP-induced vasoconstriction.

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          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          23 September 2008
          : 21
          : 2
          : 98-104
          Department of Physiology and Research Laboratory for Cardiovascular Diseases, Shinshu University School of Medicine, Matsumoto, Japan
          158500 Blood Vessels 1984;21:98–104
          © 1984 S. Karger AG, Basel

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          Pages: 7
          Research Paper


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