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      HIV infection, inflammation, immunosenescence, and aging.

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      Annual review of medicine
      Annual Reviews

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          Abstract

          Although antiretroviral therapy for HIV infection prevents AIDS-related complications and prolongs life, it does not fully restore health. Long-term treated patients remain at higher than expected risk for a number of complications typically associated with aging, including cardiovascular disease, cancer, osteoporosis, and other end-organ diseases. The potential effect of HIV on health is perhaps most clearly exhibited by a number of immunologic abnormalities that persist despite effective suppression of HIV replication. These changes are consistent with some of the changes to the adaptive immune system that are seen in the very old ("immunosenescence") and that are likely related in part to persistent inflammation. HIV-associated inflammation and immunosenescence have been implicated as causally related to the premature onset of other end-organ diseases. Novel therapeutic strategies aimed at preventing or reversing these immunologic defects may be necessary if HIV-infected patients are to achieve normal life span.

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          Author and article information

          Journal
          Annu Rev Med
          Annual review of medicine
          Annual Reviews
          1545-326X
          0066-4219
          2011
          : 62
          Affiliations
          [1 ] Department of Medicine, San Francisco General Hospital, University of California San Francisco, CA, USA. sdeeks@php.ucsf.edu
          Article
          NIHMS504909
          10.1146/annurev-med-042909-093756
          3759035
          21090961
          10ba7273-c378-4f53-b496-560f0d9245ce
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