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Association of C4d deposition with clinical outcomes in IgA nephropathy.
Mario Espinosa
1 ,
Rosa Ortega ,
Marina Sánchez ,
Alfons Segarra ,
Maria Teresa Salcedo ,
Fayna González ,
Rafael Camacho ,
Miguel Angel Valdivia ,
Rocio Cabrera ,
Katia López ,
Fernando Pinedo ,
Eduardo Gutierrez ,
Alfonso Valera ,
Miryam Leon ,
Maria Angeles Cobo ,
Rosa Rodriguez ,
Jose Ballarín ,
Yolanda Arce ,
Beatriz García ,
María Dolores Muñoz ,
Manuel Praga
May 2014
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Abstract
Several studies have suggested that activation of the complement system is a contributing pathogenic mechanism in IgA nephropathy (IgAN). C4d staining is an inexpensive and easy-to-perform method for the analysis of renal biopsies. This study aimed to assess the clinical and prognostic implications of C4d staining in IgAN.