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No influence of antihypertensive agents on plasma free metanephrines.

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      Abstract

      Hypertension can be the predominant sign of pheochromocytoma (PCC) and sympathetic paraganglioma (sPGL) and screening for PCC/sPGL is often performed in patients who are already being treated with antihypertensive agents. There is very little information about the influence of antihypertensive drugs on plasma free metanephrines. The aim of this study was to determine whether commonly prescribed antihypertensive drugs can falsely elevate plasma free metanephrines concentrations measured by LC-MS/MS analysis.

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      Affiliations
      [1 ] Department of Endocrinology (AA31), University of Groningen, University Medical Center Groningen, PO-box 30.001, 9700 RB Groningen, The Netherlands. Electronic address: t.osinga@umcg.nl.
      [2 ] Department of Laboratory Medicine (EA61), University of Groningen, University Medical Center Groningen, PO-box 30.001, 9700 RB Groningen, The Netherlands. Electronic address: i.p.kema@umcg.nl.
      [3 ] Department of Endocrinology (AA31), University of Groningen, University Medical Center Groningen, PO-box 30.001, 9700 RB Groningen, The Netherlands. Electronic address: m.n.kerstens@umcg.nl.
      [4 ] Department of Laboratory Medicine (EA61), University of Groningen, University Medical Center Groningen, PO-box 30.001, 9700 RB Groningen, The Netherlands. Electronic address: w.h.a.de.jong@umcg.nl.
      [5 ] Department of Laboratory Medicine (EA61), University of Groningen, University Medical Center Groningen, PO-box 30.001, 9700 RB Groningen, The Netherlands. Electronic address: h.j.r.van.faassen@umcg.nl.
      [6 ] Department of Endocrinology (AA31), University of Groningen, University Medical Center Groningen, PO-box 30.001, 9700 RB Groningen, The Netherlands. Electronic address: r.p.f.dullaart@umcg.nl.
      [7 ] Department of Endocrinology (AA31), University of Groningen, University Medical Center Groningen, PO-box 30.001, 9700 RB Groningen, The Netherlands. Electronic address: t.p.links@umcg.nl.
      [8 ] Department of Endocrinology (AA31), University of Groningen, University Medical Center Groningen, PO-box 30.001, 9700 RB Groningen, The Netherlands. Electronic address: a.n.a.van.der.horst@umcg.nl.
      Journal
      Clin. Biochem.
      Clinical biochemistry
      Elsevier BV
      1873-2933
      0009-9120
      Dec 2016
      : 49
      : 18
      27291837 S0009-9120(16)30100-X 10.1016/j.clinbiochem.2016.06.004

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