No influence of antihypertensive agents on plasma free metanephrines.

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Abstract

Hypertension can be the predominant sign of pheochromocytoma (PCC) and sympathetic paraganglioma (sPGL) and screening for PCC/sPGL is often performed in patients who are already being treated with antihypertensive agents. There is very little information about the influence of antihypertensive drugs on plasma free metanephrines. The aim of this study was to determine whether commonly prescribed antihypertensive drugs can falsely elevate plasma free metanephrines concentrations measured by LC-MS/MS analysis.

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Journal

Journal ID (iso-abbrev): Clin. Biochem.

Title: Clinical biochemistry

Publisher: Elsevier BV

ISSN (Electronic): 1873-2933

ISSN (Print): 0009-9120

Publication date (Electronic): Dec 2016

Volume: 49

Issue: 18

Affiliations

[1 ] Department of Endocrinology (AA31), University of Groningen, University Medical Center Groningen, PO-box 30.001, 9700 RB Groningen, The Netherlands. Electronic address: t.osinga@umcg.nl.

[2 ] Department of Laboratory Medicine (EA61), University of Groningen, University Medical Center Groningen, PO-box 30.001, 9700 RB Groningen, The Netherlands. Electronic address: i.p.kema@umcg.nl.

[3 ] Department of Endocrinology (AA31), University of Groningen, University Medical Center Groningen, PO-box 30.001, 9700 RB Groningen, The Netherlands. Electronic address: m.n.kerstens@umcg.nl.

[4 ] Department of Laboratory Medicine (EA61), University of Groningen, University Medical Center Groningen, PO-box 30.001, 9700 RB Groningen, The Netherlands. Electronic address: w.h.a.de.jong@umcg.nl.

[5 ] Department of Laboratory Medicine (EA61), University of Groningen, University Medical Center Groningen, PO-box 30.001, 9700 RB Groningen, The Netherlands. Electronic address: h.j.r.van.faassen@umcg.nl.

[6 ] Department of Endocrinology (AA31), University of Groningen, University Medical Center Groningen, PO-box 30.001, 9700 RB Groningen, The Netherlands. Electronic address: r.p.f.dullaart@umcg.nl.

[7 ] Department of Endocrinology (AA31), University of Groningen, University Medical Center Groningen, PO-box 30.001, 9700 RB Groningen, The Netherlands. Electronic address: t.p.links@umcg.nl.

[8 ] Department of Endocrinology (AA31), University of Groningen, University Medical Center Groningen, PO-box 30.001, 9700 RB Groningen, The Netherlands. Electronic address: a.n.a.van.der.horst@umcg.nl.

Article

Publisher Item ID: S0009-9120(16)30100-X

DOI: 10.1016/j.clinbiochem.2016.06.004

PubMed ID: 27291837

SO-VID: 10c500de-ed56-4011-bd51-e50b31262fd1

History

Keywords: Pheochromocytoma,Metanephrines,Antihypertensive medication,β-blockers

Data availability:

Keywords: Pheochromocytoma, Metanephrines, Antihypertensive medication, β-blockers

No influence of antihypertensive agents on plasma free metanephrines.

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