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      No influence of antihypertensive agents on plasma free metanephrines.

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          Abstract

          Hypertension can be the predominant sign of pheochromocytoma (PCC) and sympathetic paraganglioma (sPGL) and screening for PCC/sPGL is often performed in patients who are already being treated with antihypertensive agents. There is very little information about the influence of antihypertensive drugs on plasma free metanephrines. The aim of this study was to determine whether commonly prescribed antihypertensive drugs can falsely elevate plasma free metanephrines concentrations measured by LC-MS/MS analysis.

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          Author and article information

          Journal
          Clin. Biochem.
          Clinical biochemistry
          Elsevier BV
          1873-2933
          0009-9120
          Dec 2016
          : 49
          : 18
          Affiliations
          [1 ] Department of Endocrinology (AA31), University of Groningen, University Medical Center Groningen, PO-box 30.001, 9700 RB Groningen, The Netherlands. Electronic address: t.osinga@umcg.nl.
          [2 ] Department of Laboratory Medicine (EA61), University of Groningen, University Medical Center Groningen, PO-box 30.001, 9700 RB Groningen, The Netherlands. Electronic address: i.p.kema@umcg.nl.
          [3 ] Department of Endocrinology (AA31), University of Groningen, University Medical Center Groningen, PO-box 30.001, 9700 RB Groningen, The Netherlands. Electronic address: m.n.kerstens@umcg.nl.
          [4 ] Department of Laboratory Medicine (EA61), University of Groningen, University Medical Center Groningen, PO-box 30.001, 9700 RB Groningen, The Netherlands. Electronic address: w.h.a.de.jong@umcg.nl.
          [5 ] Department of Laboratory Medicine (EA61), University of Groningen, University Medical Center Groningen, PO-box 30.001, 9700 RB Groningen, The Netherlands. Electronic address: h.j.r.van.faassen@umcg.nl.
          [6 ] Department of Endocrinology (AA31), University of Groningen, University Medical Center Groningen, PO-box 30.001, 9700 RB Groningen, The Netherlands. Electronic address: r.p.f.dullaart@umcg.nl.
          [7 ] Department of Endocrinology (AA31), University of Groningen, University Medical Center Groningen, PO-box 30.001, 9700 RB Groningen, The Netherlands. Electronic address: t.p.links@umcg.nl.
          [8 ] Department of Endocrinology (AA31), University of Groningen, University Medical Center Groningen, PO-box 30.001, 9700 RB Groningen, The Netherlands. Electronic address: a.n.a.van.der.horst@umcg.nl.
          Article
          S0009-9120(16)30100-X
          10.1016/j.clinbiochem.2016.06.004
          27291837

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