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      Updating P300: An integrative theory of P3a and P3b

      Clinical Neurophysiology

      Elsevier BV

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          Abstract

          The empirical and theoretical development of the P300 event-related brain potential (ERP) is reviewed by considering factors that contribute to its amplitude, latency, and general characteristics. The neuropsychological origins of the P3a and P3b subcomponents are detailed, and how target/standard discrimination difficulty modulates scalp topography is discussed. The neural loci of P3a and P3b generation are outlined, and a cognitive model is proffered: P3a originates from stimulus-driven frontal attention mechanisms during task processing, whereas P3b originates from temporal-parietal activity associated with attention and appears related to subsequent memory processing. Neurotransmitter actions associating P3a to frontal/dopaminergic and P3b to parietal/norepinephrine pathways are highlighted. Neuroinhibition is suggested as an overarching theoretical mechanism for P300, which is elicited when stimulus detection engages memory operations.

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          Author and article information

          Journal
          Clinical Neurophysiology
          Clinical Neurophysiology
          Elsevier BV
          13882457
          October 2007
          October 2007
          : 118
          : 10
          : 2128-2148
          10.1016/j.clinph.2007.04.019
          2715154
          17573239
          © 2007

          https://www.elsevier.com/tdm/userlicense/1.0/

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