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      Leptin resistance - or why leptin fails to work in obesity.

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          Abstract

          In experimental models of obesity high serum concentrations of leptin without subsequent inhibition of food intake indicate a resistance to the physiological effects of leptin. Similar to the animal model leptin concentrations in most of the obese patients are higher compared to normal-weight persons. The postulated leptin resistance is one major target in the search for a better understanding of obesity and the development of pharmacological tools to treat this spreading disease.

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          Author and article information

          Journal
          Exp. Clin. Endocrinol. Diabetes
          Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association
          Georg Thieme Verlag KG
          0947-7349
          0947-7349
          Feb 2003
          : 111
          : 1
          Affiliations
          [1 ] Department of Endocrinology and Metabolism, Otto-Von-Guericke University, Magdeburg, Germany.
          Article
          10.1055/s-2003-37492
          12605342
          10cd66c8-a8db-4e92-8205-b9fc674bfca9
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