50
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Enigmatic Kikuchi-Fujimoto disease: a comprehensive review.

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          To determine the clinicopathologic significance of Kikuchi-Fujimoto disease (KFD) and review the literature on this condition, we conducted a MEDLINE search of English-language articles published between 1972 and December 2003. KFD has a worldwide distribution, and Asiatic people have a higher prevalence. Its pathogenesis remains controversial. Patients are young and seek care because of acute tender, cervical lymphadenopathy and low-grade fever. Histologic findings include paracortical areas of coagulative necrosis with abundant karyorrhectic debris. Karyorrhectic foci consist of various types of histiocytes, plasmacytoid monocytes, immunoblasts, and small and large lymphocytes. There is an abundance of T cells with predominance of CD8+ over CD4+ T cells. Differential diagnosis includes lymphoma, lymphadenitis associated with systemic lupus erythematosus, and even adenocarcinoma. KFD is an uncommon, self-limited, and perhaps underdiagnosed process with an excellent prognosis. Accurate clinicopathologic recognition is crucial, particularly because KFD can be mistaken for malignant lymphoma.

          Related collections

          Author and article information

          Journal
          Am J Clin Pathol
          American journal of clinical pathology
          American Society for Clinical Pathology (ASCP)
          0002-9173
          0002-9173
          Jul 2004
          : 122
          : 1
          Affiliations
          [1 ] Department of Internal Medicine, Hospital Clinic, University of Barcelona, Spain. bosch@medicina.ub.es
          Article
          10.1309/YF08-1L4T-KYWV-YVPQ
          15272543
          10d106ee-3166-4096-bdfc-4303f38bf76a
          History

          Comments

          Comment on this article