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      The Effect of Nifedipine on Normal and Ischemic Left Ventricular Function during Atrial Pacing Stress

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          Abstract

          We studied 44 patients (group I: 9 with insignificant disease and group II: 35 with significant coronary artery disease) by nuclear angiography during the controlled increase in heart rate by atrial pacing to evaluate the effect of 20 mg of sublingual nifedipine on left ventricular function. Left ventricular volumes were calculated using count-derived changes: end-diastolic (EDE), end-systolic (ESE), stroke volume (SVE) and cardiac output equivalents (COE) and ejection fraction (EF) and ejection rate (ER) were calculated during basal sinus rhythm (C) and at the maximal atrial pacing (AP) rate with and without nifedipine. In normal subjects, AP decreased ventricular volumes. The administration of nifedipine decreased blood pressure but had no further effect on left ventricular volume. In the ischemic ventricle, AP produced reversible ventricular wall paresis with a smaller decrease in EDE, an increase in ESE and a significant fall in EF. Nifedipine induced a striking improvement in EF and ER. This was probably a consequence of afterload reduction and increased coronary blood flow.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1984
          1984
          11 November 2008
          : 71
          : 4
          : 190-198
          Affiliations
          Department of Cardiology, Hadassah-Hebrew University Hospital, Jerusalem, Israel
          Article
          173664 Cardiology 1984;71:190–198
          10.1159/000173664
          6478465
          © 1984 S. Karger AG, Basel

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          Page count
          Pages: 9
          Categories
          Original Paper

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