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      Anticataractogenic Property of γ-Glutamylcysteine Ethyl Ester in an Animal Model of Cataract

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          The anticataractogenic potential of γ-glutamylcysteine ethyl ester was investigated in model cataracts induced by L-buthionine sulfoximine. Subcutaneous injection of the ester (0.625–2.5 mmol/kg) effectively inhibited cataractogenesis in suckling mice. Treatment of mice with L-buthionine sulfoximine alone resulted in a marked reduction of the glutathione content in the eyes. This deprivation of glutathione was mitigated, to a significant degree, by coadministering γ-glutamylcysteine ethyl ester. In an experiment with rat lens in culture, γ-glutamylcysteine ethyl ester was found to elevate the lenticular level of glutathione. These results indicate that γ-glutamylcysteine ethyl ester is able to permeate across biomembranes and serves as an excellent precursor for glutathione biosynthesis, thereby exerting its anticataractogenic activity.

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          Author and article information

          Ophthalmic Res
          Ophthalmic Research
          S. Karger AG
          10 December 2009
          : 23
          : 1
          : 51-58
          Teijin Insitute for Biomedical Research, Tokyo, Japan
          267088 Ophthalmic Res 1991;23:51–58
          © 1991 S. Karger AG, Basel

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          Pages: 8
          Original Paper


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