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      Metabolism of Prostaglandin F2α in Early Human Placenta in vitro


      Hormone Research in Paediatrics

      S. Karger AG

      Metabolism, Prostaglandin F2α , Human placenta, <italic>In vitro</italic>

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          The authors were investigating the metabolism of prostaglandin F<sub>2α</sub> in human early placenta, in in vitro incubation experiments. They have identified both major metabolites, 15-keto-PGF<sub>2α</sub> and 15-keto-13, 14 dehydro PGF<sub>2α</sub>. They have examined the change in the percentage of these, taken as a function of time. They have established that the main site of inactivating the endogenous PGF<sub>2α</sub> is the early human placenta. They suppose that the considerable Pg-inactiviting effect of the placenta has a part which acts as a protecting mechanism in preventing the uterotonic influence of the endogenous prostaglandins.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          25 November 2008
          : 8
          : 2
          : 99-106
          WHO Clinical Research Center on Human Reproduction, University Medical School of Szeged, Szeged
          178786 Horm Res 1977;8:99–106
          © 1977 S. Karger AG, Basel

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          Page count
          Pages: 8


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