The effect of estradiol add-back: a longitudinal MRI study in prostate cancer patients

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Abstract

We investigated the effect of estradiol add-back therapy (EAT) on brain activation related to cognitive function and affect in addition to putative changes in gray and white matter volume in testosterone depleted participants with prostate cancer. We conducted a randomized controlled, double-blinded trial in which 40 patients received 0.9 mg of transdermal estradiol per day for 6 months or matched placebo. Anatomical MRI and three functional MRI (fMRI) scans were obtained for the emotion recognition task, verbal memory task, and visuospatial memory task. Activation in corresponding cognitive and affective brain networks was demonstrated for all tasks. Longitudinally, there was no difference in brain activation, reaction time, or accuracy in response to the fMRI tasks between the EAT group and placebo group at 6 months. In addition, there was no detectable change in whole-brain gray or white matter volume or in hippocampal volume between the two groups after 6 months. This study supports earlier findings that EAT does not improve verbal memory or affect and has no immediate effect on hippocampal volume in testosterone depleted patients with prostate cancer.

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Author and article information

Journal

Journal ID (nlm-ta): Endocr Connect

Journal ID (iso-abbrev): Endocr Connect

Journal ID (hwp): EC

Title: Endocrine Connections

Publisher: Bioscientifica Ltd (Bristol )

ISSN (Electronic): 2049-3614

Publication date (Electronic): 07 February 2024

Publication date (Electronic preprint): 16 January 2024

Publication date Collection: 01 March 2024

Volume: 13

Issue: 3

Electronic Location Identifier: e230409

Affiliations

[1 ]Department of Psychiatry , University of Melbourne, Austin Health, Heidelberg, Victoria, Australia

[2 ]Department of Endocrinology , Austin Health, Heidelberg, Victoria, Australia

[3 ]Florey Institute of Neuroscience and Mental Health , Parkville, Victoria, Australia

[4 ]Department of Florey Institute , University of Melbourne, Parkville, Victoria, Australia

Author notes

Correspondence should be addressed to O Dandash: orwa.dandash@ 123456unimelb.edu.au

Author information

Orwa Dandash http://orcid.org/0000-0001-8845-7280

Article

Publisher ID: EC-23-0409

DOI: 10.1530/EC-23-0409

PMC ID: 10895318

PubMed ID: 38226639

SO-VID: 1124bb99-95f5-4b53-9b2f-beb781cd578c

License:

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

History

Date received : 01 October 2023

Date accepted : 16 January 2024

Funding

Funded by: Medical Research Council, doi http://dx.doi.org/10.13039/501100000265;

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The effect of estradiol add-back: a longitudinal MRI study in prostate cancer patients

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