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Breast cancer molecular subtypes respond differently to preoperative chemotherapy.
Roman Rouzier
1 ,
Charles M Perou ,
W Fraser Symmans ,
Nuhad Ibrahim ,
Massimo Cristofanilli ,
Keith Anderson ,
Kenneth R Hess ,
James Stec ,
Mark Ayers ,
Peter Wagner ,
Paolo Morandi ,
Chang Fan ,
Islam Rabiul ,
Jeffrey S Ross ,
Gabriel N Hortobagyi ,
Lajos Pusztai
Aug 15 2005
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Abstract
Molecular classification of breast cancer has been proposed based on gene expression profiles of human tumors. Luminal, basal-like, normal-like, and erbB2+ subgroups were identified and were shown to have different prognoses. The goal of this research was to determine if these different molecular subtypes of breast cancer also respond differently to preoperative chemotherapy.