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      Visible-Light-Mediated Monoselective Ortho C-H Arylation of 6-Arylpurine Nucleosides with Diazonium Salts.

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          Abstract

          A combined palladium- and photoredox-catalyzed monoselective arylation of 6-arylpurine nucleosides has been developed by employing purine as a directing group via the photoredox reaction, and many functional groups are well tolerated in this direct C-H arylation condition. Various of functionalized purines (nucleosides) which are potentially of great importance in medicinal chemistry could be obtained under visible light irradiation at room temperature within 4 h.

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          Author and article information

          Journal
          J. Org. Chem.
          The Journal of organic chemistry
          American Chemical Society (ACS)
          1520-6904
          0022-3263
          May 18 2017
          Affiliations
          [1 ] School of Chemistry and Chemical Engineering, Henan Institute of Science and Technology , Xinxiang, Henan Province 453003, China.
          Article
          10.1021/acs.joc.7b00659
          28485138
          115e8a37-f236-49ff-bfd4-29b623944238
          History

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