BDNF methylation and depressive disorder in acute coronary syndrome: The K-DEPACS and EsDEPACS studies.

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Abstract

Epigenetic regulation investigated by methylation tests has been associated with pathogenesis and treatment response in depressive disorders. However, these hypotheses have rarely been tested in patients with acute coronary syndrome (ACS) vulnerable to depression. This study aimed to investigate whether brain derived neurotrophic factor (BDNF) methylation status is associated with occurrence and treatment response of depressive disorder in ACS.

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Author and article information

Journal

Journal ID (iso-abbrev): Psychoneuroendocrinology

Title: Psychoneuroendocrinology

Publisher: Elsevier BV

ISSN (Electronic): 1873-3360

ISSN (Print): 0306-4530

Publication date (Electronic): Dec 2015

Volume: 62

Affiliations

[1 ] Department of Psychiatry, Chonnam National University Medical School, Gwangju, South Korea. Electronic address: jmkim@chonnam.ac.kr.

[2 ] King's College London, Institute of Psychiatry, London, UK. Electronic address: r.stewart@iop.kcl.ac.uk.

[3 ] Department of Psychiatry, Chonnam National University Medical School, Gwangju, South Korea. Electronic address: hjkang82@chonnam.ac.kr.

[4 ] Department of Psychiatry, Chonnam National University Medical School, Gwangju, South Korea. Electronic address: kybae1@chonnam.ac.kr.

[5 ] Department of Psychiatry, Chonnam National University Medical School, Gwangju, South Korea. Electronic address: swkim@chonnam.ac.kr.

[6 ] Department of Psychiatry, Chonnam National University Medical School, Gwangju, South Korea. Electronic address: isshin@chonnam.ac.kr.

[7 ] Department of Cardiology, Chonnam National University Medical School, Gwangju, South Korea. Electronic address: hyj200@chonnam.ac.kr.

[8 ] Department of Cardiology, Chonnam National University Medical School, Gwangju, South Korea. Electronic address: cecilyk@chonnam.ac.kr.

[9 ] Department of Cardiology, Chonnam National University Medical School, Gwangju, South Korea. Electronic address: mhjeong@chonnam.ac.kr.

[10 ] Department of Psychiatry, Chonnam National University Medical School, Gwangju, South Korea. Electronic address: jsyoon@chonnam.ac.kr.

Article

Publisher Item ID: S0306-4530(15)00886-0

DOI: 10.1016/j.psyneuen.2015.08.013

PubMed ID: 26313133

SO-VID: 1175bd9a-fcd1-45d3-8814-ea21c32e3da9

History

Keywords: Methylation,Acute coronary syndrome,BDNF,Depression,Epigenetics

Data availability:

Keywords: Methylation, Acute coronary syndrome, BDNF, Depression, Epigenetics

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