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BDNF methylation and depressive disorder in acute coronary syndrome: The K-DEPACS and EsDEPACS studies.

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      Abstract

      Epigenetic regulation investigated by methylation tests has been associated with pathogenesis and treatment response in depressive disorders. However, these hypotheses have rarely been tested in patients with acute coronary syndrome (ACS) vulnerable to depression. This study aimed to investigate whether brain derived neurotrophic factor (BDNF) methylation status is associated with occurrence and treatment response of depressive disorder in ACS.

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      Affiliations
      [1 ] Department of Psychiatry, Chonnam National University Medical School, Gwangju, South Korea. Electronic address: jmkim@chonnam.ac.kr.
      [2 ] King's College London, Institute of Psychiatry, London, UK. Electronic address: r.stewart@iop.kcl.ac.uk.
      [3 ] Department of Psychiatry, Chonnam National University Medical School, Gwangju, South Korea. Electronic address: hjkang82@chonnam.ac.kr.
      [4 ] Department of Psychiatry, Chonnam National University Medical School, Gwangju, South Korea. Electronic address: kybae1@chonnam.ac.kr.
      [5 ] Department of Psychiatry, Chonnam National University Medical School, Gwangju, South Korea. Electronic address: swkim@chonnam.ac.kr.
      [6 ] Department of Psychiatry, Chonnam National University Medical School, Gwangju, South Korea. Electronic address: isshin@chonnam.ac.kr.
      [7 ] Department of Cardiology, Chonnam National University Medical School, Gwangju, South Korea. Electronic address: hyj200@chonnam.ac.kr.
      [8 ] Department of Cardiology, Chonnam National University Medical School, Gwangju, South Korea. Electronic address: cecilyk@chonnam.ac.kr.
      [9 ] Department of Cardiology, Chonnam National University Medical School, Gwangju, South Korea. Electronic address: mhjeong@chonnam.ac.kr.
      [10 ] Department of Psychiatry, Chonnam National University Medical School, Gwangju, South Korea. Electronic address: jsyoon@chonnam.ac.kr.
      Journal
      Psychoneuroendocrinology
      Psychoneuroendocrinology
      Elsevier BV
      1873-3360
      0306-4530
      Dec 2015
      : 62
      26313133
      S0306-4530(15)00886-0
      10.1016/j.psyneuen.2015.08.013

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