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      BDNF methylation and depressive disorder in acute coronary syndrome: The K-DEPACS and EsDEPACS studies.

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          Abstract

          Epigenetic regulation investigated by methylation tests has been associated with pathogenesis and treatment response in depressive disorders. However, these hypotheses have rarely been tested in patients with acute coronary syndrome (ACS) vulnerable to depression. This study aimed to investigate whether brain derived neurotrophic factor (BDNF) methylation status is associated with occurrence and treatment response of depressive disorder in ACS.

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          Author and article information

          Journal
          Psychoneuroendocrinology
          Psychoneuroendocrinology
          Elsevier BV
          1873-3360
          0306-4530
          Dec 2015
          : 62
          Affiliations
          [1 ] Department of Psychiatry, Chonnam National University Medical School, Gwangju, South Korea. Electronic address: jmkim@chonnam.ac.kr.
          [2 ] King's College London, Institute of Psychiatry, London, UK. Electronic address: r.stewart@iop.kcl.ac.uk.
          [3 ] Department of Psychiatry, Chonnam National University Medical School, Gwangju, South Korea. Electronic address: hjkang82@chonnam.ac.kr.
          [4 ] Department of Psychiatry, Chonnam National University Medical School, Gwangju, South Korea. Electronic address: kybae1@chonnam.ac.kr.
          [5 ] Department of Psychiatry, Chonnam National University Medical School, Gwangju, South Korea. Electronic address: swkim@chonnam.ac.kr.
          [6 ] Department of Psychiatry, Chonnam National University Medical School, Gwangju, South Korea. Electronic address: isshin@chonnam.ac.kr.
          [7 ] Department of Cardiology, Chonnam National University Medical School, Gwangju, South Korea. Electronic address: hyj200@chonnam.ac.kr.
          [8 ] Department of Cardiology, Chonnam National University Medical School, Gwangju, South Korea. Electronic address: cecilyk@chonnam.ac.kr.
          [9 ] Department of Cardiology, Chonnam National University Medical School, Gwangju, South Korea. Electronic address: mhjeong@chonnam.ac.kr.
          [10 ] Department of Psychiatry, Chonnam National University Medical School, Gwangju, South Korea. Electronic address: jsyoon@chonnam.ac.kr.
          S0306-4530(15)00886-0
          10.1016/j.psyneuen.2015.08.013
          26313133

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