Synthesis and Antiulcer Activity Studies of 2-(1′-Iminothioimido Substituted)-1′-Substituted Phenylbenzoic acids

Abstract

Certain 2-(1'-iminothioimido substituted)-1'-substituted phenybenzoic acids (P _1-9) were synthesized by reaction of phthalic anhydride with benzotriazole, 2-mercapto benzothiazole and 2-p-amino phenyl benzimidazole, respectively (A _1-3) followed by imine formation with Schiff bases of thiourea with salicylaldehyde, furfuraldehyde and 1-phenyl-3-methyl-5-pyrazolone. Antiulcer activity was evaluated using reduction in total acidity, free acidity and ulcer index as parameters. Compounds P ₃, P ₆, P ₇ and P ₉(100 mg/kg) showed significant (P< 0.001) antiulcer action compared to control and omeprazole (40 mg/kg).