Comparative study of the correlation between atherosclerosis and osteoporosis in women in Japan and Mongolia

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Abstract

Objective

Associations between vascular calcification and osteoporosis are well documented, yet effects of lifestyle on atherosclerosis and osteoporosis remain unclear. This study evaluated the relationship between atherosclerosis and osteoporosis of people with different lifestyles living on Uku Island in Japan (rice consumption and fishing lifestyle) and in Ulaanbaatar in Mongolia (meat consumption and nomadic lifestyle), and investigated the differences of lifestyles on atherosclerosis and osteoporosis.

Methods

Participants were women aged over 50 years who had undergone a previous medical examination for atherosclerosis and osteoporosis (Uku Island, 104, Ulaanbaatar, 71). Lifestyle habits were obtained by questionnaire. Bone mineral density of the right calcaneus was measured using quantitative ultrasound. Brachial‐ankle pulse wave velocity was measured as an index of atherosclerosis.

Results

There were no significant differences in bone mineral density and brachial‐ankle pulse wave velocity between the two groups, even though meat and dairy intake, number of meals skipped, and number of children were significantly greater in participants from Ulaanbaatar compared with Uku Island. Brachial‐ankle pulse wave velocity showed significant positive correlations with age, systolic and diastolic blood pressures, and body mass index and a significant negative correlation with bone mineral density for both groups. With step‐wise multiple regression analysis, brachial‐ankle pulse wave velocity significantly correlated with age and bone mineral density for both populations. Systolic blood pressure significantly correlated with brachial‐ankle pulse wave velocity for the Ulaanbaatar group.

Conclusions

Despite significant lifestyle differences, similar relationships between atherosclerosis and osteoporosis were observed in women from Uku Island and Ulaanbaatar. Hypertension was a significant contributing factor for atherosclerosis for the Ulaanbaatar group.

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Most cited references 29

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Validity, reproducibility, and clinical significance of noninvasive brachial-ankle pulse wave velocity measurement.

Akira Yamashina, Hirofumi Tomiyama, Kazuhiro Takeda … (2002)

The present study was conducted to evaluate the validity and reproducibility of noninvasive brachial-ankle pulse wave velocity (baPWV) measurements and to examine the alteration of baPWV in patients with coronary artery disease (CAD). Simultaneous recordings of baPWV by a simple, noninvasive method and aortic pulse wave velosity (PWV) using a catheter tip with pressure manometer were performed in 41 patients with CAD, vasospastic angina, or cardiomyopathy. In 32 subjects (15 controls and 17 patients with CAD), baPWV was recorded independently by two observers in a random manner. In 55 subjects (14 controls and 41 patients with CAD), baPWV was recorded twice by a single observer on different days. baPWV were compared among 172 patients with CAD (aged 62 +/- 8 years); 655 age-matched patients without CAD but with hypertension, diabetes mellitus, or dyslipidemia; and 595 age-matched healthy subjects without these risk factors. baPWV correlated well with aortic PWV (r=0.87, p<0.01). Pearson's correlation coefficients of interobserver and intraobserver reproducibility were r=0.98 and r=0.87, respectively. The corresponding coefficients of variation were 8.4% and 10.0%. baPWV were significantly higher in CAD patients than in non-CAD patients with risk factors, for both genders (p<0.01). In addition, baPWV were higher in non-CAD patients with risk factors than in healthy subjects without risk factors. Thus, the validity and reproducibility of baPWV measurements are considerably high, and this method seems to be an acceptable marker reflecting vascular damages. baPWV measured by this simple, noninvasive method is suitable for screening vascular damages in a large population.

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Aortic calcification and the risk of osteoporosis and fractures.

Vicente Gilsanz, James Sayre, Kiumars Arfai … (2004)

We investigated the relation between computed tomography measures of aortic calcification and values for bone density and the number of fragility fractures in 2348 healthy, postmenopausal women. To determine whether increases in vascular calcification and bone loss progress in parallel, baseline values were compared with measurements obtained 9 months to 8 yr later in a subgroup of 228 women. Of the 2348 subjects studied, 70% had osteoporosis, 30% had at least one vertebral fracture, and 9% had at least one hip fracture. Aortic calcifications were inversely related to bone density and directly related to fractures. After adjusting for age and potential confounders, measures for aortic calcification predicted 26.1% of the variance in bone density (P < 0.001). Compared with women without calcification, the odds ratios for vertebral and hip fractures in those with calcification were estimated to be 4.8 (95% confidence interval, 3.6-6.5) and 2.9 (95% confidence interval, 1.8-4.8), respectively. The subgroup analysis of 228 women longitudinally studied showed that the percentage of yearly increase in aortic calcification accounted for 47% of the variance in the percentage rate of bone loss (P < 0.001). Moreover, a strong graded association was observed between the progression of vascular calcification and bone loss for each quartile. Women in the highest quartile for gains in aortic calcification had four times greater yearly bone loss (5.3 vs.1.3% yearly; P < 0.001) than women of similar age in the lowest quartile. Smaller, but highly significant differences were also found between all other quartiles. We conclude that aortic calcifications are a strong predictor for low bone density and fragility fractures.

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Diagnostic criteria for primary osteoporosis: year 2000 revision.

Hiroto Tanaka, Y. Oh, … (2000)

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Author and article information

Contributors

Kazuo Muta: info@seiwakai-muta-hp.or.jp

Journal

Journal ID (nlm-ta): J Gen Fam Med

Journal ID (iso-abbrev): J Gen Fam Med

Journal ID (doi): 10.1002/(ISSN)2189-7948

Journal ID (publisher-id): JGF2

Title: Journal of General and Family Medicine

Publisher: John Wiley and Sons Inc. (Hoboken )

ISSN (Print): 2189-6577

ISSN (Electronic): 2189-7948

Publication date (Electronic): 08 May 2017

Publication date Collection: October 2017

Volume: 18

Issue: 5 ( doiID: 10.1002/jgf2.2017.18.issue-5 )

Pages: 237-243

Affiliations

[ ¹ ] Medical Corp. Seiwakai Muta Hospital Fukuoka Japan

Author notes

[*] [* ] Correspondence

Kazuo Muta, Medical Corp., Seiwakai Muta Hospital, Fukuoka, Japan.

Email: info@ 123456seiwakai-muta-hp.or.jp

Article

Publisher ID: JGF256

DOI: 10.1002/jgf2.56

PMC ID: 5689420

SO-VID: 11d66737-8296-4ce7-8fc6-093d42421201

License:

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

History

Date received : 01 June 2016

Date accepted : 20 September 2016

Page count

Figures: 2, Tables: 2, Pages: 7, Words: 4342

Custom metadata

source-schema-version-number 2.0

component-id jgf256

cover-date October 2017

details-of-publishers-convertor Converter:WILEY_ML3GV2_TO_NLMPMC version:5.2.5 mode:remove_FC converted:16.11.2017

Keywords: arterial stiffness,bone mineral density,lifestyle,ulaanbaatar,uku island

Data availability:

Keywords: arterial stiffness, bone mineral density, lifestyle, ulaanbaatar, uku island

Comparative study of the correlation between atherosclerosis and osteoporosis in women in Japan and Mongolia

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Abstract

Objective

Methods

Results

Conclusions

Related collections

Paleontology of Mongolia

Most cited references 29

Validity, reproducibility, and clinical significance of noninvasive brachial-ankle pulse wave velocity measurement.

Aortic calcification and the risk of osteoporosis and fractures.

Diagnostic criteria for primary osteoporosis: year 2000 revision.

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