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      Neocortical neurogenesis and neuronal migration.

      1 ,
      Wiley interdisciplinary reviews. Developmental biology

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          Abstract

          The neocortex, the evolutionarily newest part of the cerebral cortex, controls nearly all aspects of behavior, including perception, language, and decision making. It contains an immense number of neurons that can be broadly divided into two groups, excitatory neurons and inhibitory interneurons. These neurons are predominantly produced through extensive progenitor cell divisions during the embryonic stages. Moreover, they are not randomly dispersed, but spatially organized into horizontal layers that are essential for neocortex function. The formation of this laminar structure requires exquisite control of neuronal migration from their birthplace to their final destination. Extensive research over the past decade has greatly advanced our understanding of the production and migration of both excitatory neurons and inhibitory interneurons in the developing neocortex. In this review, we aim to give an overview on the molecular and cellular processes of neocortical neurogenesis and neuronal migration.

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          Author and article information

          Journal
          Wiley Interdiscip Rev Dev Biol
          Wiley interdisciplinary reviews. Developmental biology
          1759-7692
          1759-7684
          Jul 2013
          : 2
          : 4
          Affiliations
          [1 ] Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA; BCMB Graduate Program, Weill Cornell Medical College, New York, NY, USA.
          Article
          NIHMS403205
          10.1002/wdev.88
          3767922
          24014417
          11d8722b-2839-4794-8f71-9df28923df5c
          Copyright © 2012 Wiley Periodicals, Inc.
          History

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