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      Nitric oxide synthase activity in infantile hypertrophic pyloric stenosis.

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          Abstract

          Hypertrophic pyloric stenosis is a common infantile disorder characterized by enlarged pyloric musculature and gastric-outlet obstruction. Its physiopathologic mechanism is not known, but a defect in pyloric relaxation (pylorospasm) has been postulated. Nitric oxide is a mediator of relaxation in the mammalian digestive tract, raising the possibility that pylorospasm could be caused by a defect in nitric oxide production. Since neuronal nitric oxide synthase and NADPH diaphorase are identical, we used the NADPH diaphorase histochemical reaction to study the distribution of nitric oxide synthase in pyloric tissue from patients with infantile hypertrophic pyloric stenosis.

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          Author and article information

          Journal
          N. Engl. J. Med.
          The New England journal of medicine
          New England Journal of Medicine (NEJM/MMS)
          0028-4793
          0028-4793
          Aug 20 1992
          : 327
          : 8
          Affiliations
          [1 ] Laboratory of Neuropathology and Neuropeptide Research, Erasme Academic Hospital, Brussels, Belgium.
          Article
          10.1056/NEJM199208203270802
          1378938
          11e2cb86-c949-4c75-8222-72a16bd9044a
          History

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