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      Endothelial Dysfunction in Uraemia

      Blood Purification

      S. Karger AG

      Endothelial function, Renal failure, Nitric oxide, Atheroma, Free radicals

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          Abstract

          Cardiovascular disease is a major cause of morbidity and mortality in chronic renal failure (CRF). The endothelium plays a central role in the control of many aspects of vascular function, and abnormalities may contribute to the generation of atherosclerosis. The endothelium produces a wide range of regulatory molecules which, in health, function in concert to provide a carefully balanced anti-atherogenic environment. Endothelial dysfunction has been repeatedly demonstrated in renal failure, is present in the absence of anatomically obvious disease and appears to be useful in the prediction of morbidity and mortality in other cardiovascular risk groups. One of the most intensively studied and important mediators of endothelial function is nitric oxide (NO), whose production is reduced in CRF. A number of possible mechanisms for reduced NO bioavailability have been investigated including substrate limitation, competitive inhibition of NO synthase by endogenous NO synthase inhibitors known to accumulate in renal failure, and premature quenching of NO by free radicals present in high concentrations in this group. A clearer understanding of the pathogenesis of endothelial dysfunction in CRF has potential clinical implications. It may provide avenues for therapeutic interventions before the onset of clinically obvious cardiovascular disease in this high-risk patient group.

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          Most cited references 1

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          Secondary prevention with antioxidants of cardiovascular disease in endstage renal disease (SPACE): randomised placebo-controlled trial

           U Gafter,  A Iaina,  A. Knecht (2000)
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            Author and article information

            Journal
            BPU
            Blood Purif
            10.1159/issn.0253-5068
            Blood Purification
            S. Karger AG
            978-3-8055-7480-8
            978-3-318-00898-2
            0253-5068
            1421-9735
            2002
            2002
            30 August 2002
            : 20
            : 5
            : 459-461
            Affiliations
            Department of Medicine, Centre for Clinical Pharmacology and Therapeutics, London, UK
            Article
            63552 Blood Purif 2002;20:459–461
            10.1159/000063552
            12207092
            © 2002 S. Karger AG, Basel

            Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

            Page count
            References: 9, Pages: 3
            Product
            Self URI (application/pdf): https://www.karger.com/Article/Pdf/63552
            Categories
            Proceedings

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