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      Unmet Needs for a Rapid Diagnosis of Chikungunya Virus Infection

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          Abstract

          Rapid Diagnosis of Chikungunya Virus Infection

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          Evaluation of two IgM rapid immunochromatographic tests during circulation of Asian lineage Chikungunya virus.

          Edwin Surya, Deni P R Butarbutar, Susana Widjaja … (2011)
          Chikungunya is an emerging viral disease, which is clinically difficult to distinguish from dengue. Current laboratory methods to diagnose chikungunya infection, such as virus isolation, RT-PCR and ELISA, are not readily available in many clinical settings. In order to provide a rapid and easy method for the diagnosis of chikungunya infection, rapid immunochromatographic tests to detect chikungunya IgM have recently become commercially available. The sensitivity and specificity of the OnSite Chikungunya IgM Rapid Test-Cassette and the SD Bioline CHIK IgM rapid test were evaluated in comparison to a capture ELISA. The sensitivity of the OnSite test was 20.5% while its specificity was 100%. The sensitivity of the SD Bioline test was 50.8% while its specificity was 89.2%. The sensitivity of the SD Bioline test increased with increasing CHIK IgM titers and with days of onset in samples collected before day 21 of illness. Increasing the reading time from the manufacturer's suggested time of 10 to 20 minutes significantly increased the sensitivity of the SD Bioline test to 68.2%, but did not significantly change its specificity.
          Article 0 comments Cited 18 times – based on 0 reviews     Review now
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            Author and article information

            Journal
            Journal ID (nlm-ta): Emerg Infect Dis
            Journal ID (iso-abbrev): Emerging Infect. Dis
            Journal ID (publisher-id): EID
            Title: Emerging Infectious Diseases
            Publisher: Centers for Disease Control and Prevention
            ISSN (Print): 1080-6040
            ISSN (Electronic): 1080-6059
            Publication date (Print): October 2016
            Volume: 22
            Issue: 10
            Pages: 1837-1839
            Affiliations
            [1]Amedeo di Savoia Hospital, Torino, Italy
            Author notes
            Address for correspondence: Elisa Burdino, Laboratory of Microbiology and Virology, Amedeo di Savoia Hospital, Corso Svizzera 164, I-10149 Torino, Italy: email: elisa.burdino@ 123456libero.it
            Article
            Publisher ID: 15-1784
            DOI: 10.3201/eid2210.151784
            PMC ID: 5038423
            PubMed ID: 27347706
            SO-VID: 11f395e5-bc4e-4f86-a585-d53b67a6df59
            History
            Categories
            Subject: Letters to the Editor
            Subject: Letters to the Editor
            Subject: Unmet Needs for a Rapid Diagnosis of Chikungunya Virus Infection

            ScienceOpen disciplines: Infectious disease & Microbiology
            Keywords: chikungunya,chikungunya virus infection,diagnosis,point-of-care assays,infections in travelers,rapid test,laboratory diagnosis,viruses,acute phase,test sensitivity,test specificity,epidemiology,outbreak control,differential diagnosis,travel-associated infection,imported cases,vector-borne infections
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            ScienceOpen disciplines: Infectious disease & Microbiology
            Keywords: chikungunya, chikungunya virus infection, diagnosis, point-of-care assays, infections in travelers, rapid test, laboratory diagnosis, viruses, acute phase, test sensitivity, test specificity, epidemiology, outbreak control, differential diagnosis, travel-associated infection, imported cases, vector-borne infections

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