5
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Brain Lactate Concentration Falls in Response to Hypoglycemia in Patients With Type 1 Diabetes and Impaired Awareness of Hypoglycemia.

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Brain lactate may be involved in the development of impaired awareness of hypoglycemia (IAH), a condition that affects approximately 25% of patients with type 1 diabetes and increases the risk of severe hypoglycemia. The aim of this study was to investigate the effect of acute hypoglycemia on brain lactate concentration in patients with IAH as compared with those with normal awareness of hypoglycemia (NAH) and healthy control subjects (n = 7 per group). After an overnight fast, all subjects underwent a two-step hyperinsulinemic euglycemic (5.0 mmol/L)-hypoglycemic (2.8 mmol/L) glucose clamp. Brain lactate concentrations were measured continuously with (1)H-MRS using a specific lactate detection method. Hypoglycemia generated symptoms in patients with NAH and healthy control subjects but not in patients with IAH. Brain lactate fell significantly by ∼20% in response to hypoglycemia in patients with type 1 diabetes with IAH but remained stable in both healthy control subjects and in patients with NAH. The fall in brain lactate is compatible with increased brain lactate oxidation providing an alternative fuel source during hypoglycemia, which may contribute to the impaired detection of hypoglycemia.

          Related collections

          Author and article information

          Journal
          Diabetes
          Diabetes
          American Diabetes Association
          1939-327X
          0012-1797
          Jun 2016
          : 65
          : 6
          Affiliations
          [1 ] Department of Radiology and Nuclear Medicine, Radboud university medical center, Nijmegen, the Netherlands evita.wiegers@radboudumc.nl.
          [2 ] Department of Internal Medicine, Radboud university medical center, Nijmegen, the Netherlands.
          [3 ] Department of Radiology and Nuclear Medicine, Radboud university medical center, Nijmegen, the Netherlands.
          [4 ] Department of Radiology and Nuclear Medicine, Radboud university medical center, Nijmegen, the Netherlands Department of Pediatrics, Radboud university medical center, Nijmegen, the Netherlands.
          Article
          db16-0068
          10.2337/db16-0068
          26993070

          Comments

          Comment on this article