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      Angiogenesis in cancer, vascular, rheumatoid and other disease.

      Nature medicine

      Vascular Endothelial Growth Factors, Vascular Endothelial Growth Factor A, Time Factors, physiopathology, Psoriasis, therapeutic use, Plasminogen, Peptide Fragments, Neovascularization, Pathologic, blood supply, Neoplasms, Neoplasm Metastasis, Mice, physiology, Lymphokines, Humans, Eye, Endothelial Growth Factors, Arthritis, Rheumatoid, Animals, Angiostatins

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          Abstract

          Recent discoveries of endogenous negative regulators of angiogenesis, thrombospondin, angiostatin and glioma-derived angiogenesis inhibitory factor, all associated with neovascularized tumours, suggest a new paradigm of tumorigenesis. It is now helpful to think of the switch to the angiogenic phenotype as a net balance of positive and negative regulators of blood vessel growth. The extent to which the negative regulators are decreased during this switch may dictate whether a primary tumour grows rapidly or slowly and whether metastases grow at all.

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          7584949

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