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Abstract
Ocular chemical injuries vary in severity, with the more severe end of the spectrum
having profound visual consequences and medicolegal implications. Grading of ocular
injuries is critical for determining acute treatment and visual prognosis. Poor immediate
management results in more challenging treatment of acute disease. Similarly, poorly
controlled acute disease results in more treatment-resistant chronic ocular disease.
Despite several decades of research and public health initiatives, simple and effective
interventions such as wearing protective eyewear and immediate irrigation of eyes
remain as key challenges. Education and prevention are therefore important public
health messages. Hurdles in the acute management of disease include poor evidence-base
for commonly used treatments (e.g. based on experimental animal studies), reduced
treatment adherence rates and high clinic non-attendance rates. The evolution of treatment
strategies, particularly limbal stem cell transplantation, has revolutionised the
visual and cosmetic outcomes in chronic phases of disease. It is therefore increasingly
important to consider tertiary referral for patients with limbal stem cell failure
or vision-limiting corneal scarring.
This study describes the long-term clinical outcomes of autologous simple limbal epithelial transplantation (SLET), a relatively new technique of limbal stem cell transplantation.