Blog
About

53
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5.

      Science (New York, N.Y.)

      Virus Replication, genetics, metabolism, physiology, Amino Acid Sequence, Animals, CHO Cells, Coxsackie and Adenovirus Receptor-Like Membrane Protein, Cricetinae, Cytopathogenic Effect, Viral, Enterovirus B, Human, Adenoviruses, Human, Gene Transfer Techniques, Genetic Vectors, HeLa Cells, Humans, Molecular Sequence Data, Receptors, Virus, chemistry, isolation & purification, Sequence Alignment, Transfection

      Read this article at

      ScienceOpenPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          A complementary DNA clone has been isolated that encodes a coxsackievirus and adenovirus receptor (CAR). When transfected with CAR complementary DNA, nonpermissive hamster cells became susceptible to coxsackie B virus attachment and infection. Furthermore, consistent with previous studies demonstrating that adenovirus infection depends on attachment of a viral fiber to the target cell, CAR-transfected hamster cells bound adenovirus in a fiber-dependent fashion and showed a 100-fold increase in susceptibility to virus-mediated gene transfer. Identification of CAR as a receptor for these two unrelated and structurally distinct viral pathogens is important for understanding viral pathogenesis and has implications for therapeutic gene delivery with adenovirus vectors.

          Related collections

          Author and article information

          Journal
          9036860

          Comments

          Comment on this article