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      Hemodynamic and Oxygen Delivery Responses to Nifedipine in Pulmonary Hypertension Secondary to Chronic Obstructive Lung Disease

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          Abstract

          The effects of a single dose of nifedipine (20 mg sublingually) on hemodynamics and tissue oxygenation were evaluated in 24 patients suffering from pulmonary hypertension secondary to severe chronic obstructive lung disease. A significant improvement in pulmonary circulation and right ventricular pump function occurred. An increase in the oxygen delivery to the tissue was also demonstrated. A complementary study in 10 patients showed that the effects observed after a single dose were still apparent after oral intake (30 mg/day) for 15 days. For these reasons nifedipine may contribute in the treatment of cor pulmonale.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1987
          1987
          11 November 2008
          : 74
          : 3
          : 196-204
          Affiliations
          aInserm, Unité 278, Unité de recherche et de valorisation en pharmococinétique et toxicocinétique, Faculté de Pharmacie; Service de Cardiologie CHU-Nord, Université d’Aix-Marseille II, et bService de Pneumologie et d’Allergie respiratoire, CHU-Nord, Université d’Aix-Marseille II, Marseille, France
          Article
          174197 Cardiology 1987;74:196–204
          10.1159/000174197
          3594508
          © 1987 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 9
          Categories
          Original Paper

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