Expression analysis of matrix metalloproteinase-13 in human gastric cancer in the presence of Helicobacter Pylori infection.

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Abstract

Matrix metalloproteinases (MMPs) can degrade essentially the extracellular matrix (ECM) components. MMPs are important regulators of tumor growth; hence the enzymes are considered as important targets for cancer therapy. MMP-13 is specially activated in gastric cancer and promotes the invasiveness of the primary tumors. Helicobacter Pylori (H.pylori) interacts with gastric epithelial cells and stimulates it to produce MMP-13in vitro.

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Author and article information

Journal

Journal ID (iso-abbrev): Cancer Biomark

Title: Cancer biomarkers : section A of Disease markers

Publisher: IOS Press

ISSN (Electronic): 1875-8592

ISSN (Print): 1574-0153

Publication date (Electronic): 2017

Volume: 18

Issue: 4

Affiliations

[1 ] Department of Biophysics, Faculty of Science, Islamic Azad University-Mashhad Branch, Mashhad, Iran.

[2 ] Immunology Research Center, BuAli Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

[3 ] Medical Genetics Research Center, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran.

[4 ] Pathology Department, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

[5 ] Department of Laboratory Sciences, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran.

Article

Publisher Item ID: CBM160127

DOI: 10.3233/CBM-160127

PubMed ID: 28128735

SO-VID: 122543cb-ddb0-4e93-b148-acd8b5877f77

History

Keywords: real-time PCR,Helicobacter Pylori,MMP-13,gastric cancer

Data availability:

Keywords: real-time PCR, Helicobacter Pylori, MMP-13, gastric cancer

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