Significance Statement We evaluate the state of the mass balance of the Antarctic Ice Sheet over the last four decades using a comprehensive, precise satellite record and output products from a regional atmospheric climate model to document its impact on sea-level rise. The mass loss is dominated by enhanced glacier flow in areas closest to warm, salty, subsurface circumpolar deep water, including East Antarctica, which has been a major contributor over the entire period. The same sectors are likely to dominate sea-level rise from Antarctica in decades to come as enhanced polar westerlies push more circumpolar deep water toward the glaciers.