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      Attacking Plasmodium vivax

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          Abstract

          Discussions beginning in 2012 ultimately led to a landmark document from the World Health Organization (WHO) titled, Control and Elimination of Plasmodium vivax: A Technical Brief, published in July 2015. That body of work represents multiple expert consultations coordinated by the WHO Global Malaria Program, along with technical consensus gathering from national malaria control programs via the WHO regional offices around the globe. That document thus represents thoroughly vetted state-of-the-art recommendations for dealing specifically with P. vivax, the first assembly of such by the WHO. This supplement to the journal was commissioned by the WHO and compiles the very substantial body of evidence and analysis informing those recommendations. This introductory narrative to the supplement provides the historical and technological context of global strategy for combatting P. vivax and reducing the burdens of morbidity and mortality it imposes.

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          Most cited references3

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          Global Technical Strategy for Malaria 2016–2030

          (2014)
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            Use of quinocide in treatment and prophylaxis of vivax malaria.

            A LYSENKO (1960)
            The discovery of antimalarial properties of derivatives of 8-aminoquinolines which combine high activity against the tissue stages of the malaria parasite with satisfactory tolerance by man can be said to have marked the final stage in the search for a radical cure of vivax malaria. Since its synthesis in the USSR in 1952, quinocide-an 8-aminoquinoline drug-has been subjected by Soviet workers to intensive research, an outline of which is presented in this paper. The results of their investigations, which ranged from laboratory and clinical studies of tolerance to the drug, through small-scale trials of its parasiticidal activity, to large-scale studies on the effectiveness of its mass administration are very encouraging. Both for anti-relapse treatment and for pre-epidemic prophylaxis, a short (10- or 14-day) course of quinocide proved as effective as a lengthy course of acriquine with plasmocide. Side-effects were infrequent, and most of those that occurred were transient and did not necessitate the suspension of treatment. It is suggested that the mass administration of quinocide would, in certain cases, be a useful adjunct to insecticidal measures in the clearance of malaria foci.
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              Control and Elimination of Plasmodium vivax: A Technical Brief

              (2015)
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                Author and article information

                Journal
                Am J Trop Med Hyg
                Am. J. Trop. Med. Hyg
                tpmd
                The American Journal of Tropical Medicine and Hygiene
                The American Society of Tropical Medicine and Hygiene
                0002-9637
                1476-1645
                28 December 2016
                28 December 2016
                : 95
                : 6 Suppl , Control and Elimination of Plasmodium vivax Malaria: The Evidence Base
                : 1-3
                Affiliations
                [1 ]Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia.
                [2 ]Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
                Author notes
                * Address correspondence to J. Kevin Baird, Eijkman-Oxford Clinical Research Unit, Jalan Diponegoro No. 69, Jakarta 10430, Indonesia. E-mail: kbaird@ 123456eocru.org
                Article
                10.4269/ajtmh.16-0517
                5201216
                27708186
                122a8193-b254-4345-9423-87982cd00ff8
                © The American Society of Tropical Medicine and Hygiene

                This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

                History
                : 24 June 2016
                : 20 August 2016
                Categories
                Articles

                Infectious disease & Microbiology
                Infectious disease & Microbiology

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