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      The plant alkaloid chelerythrine binds to chromatin, alters H3K9Ac and modulates global gene expression.

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          Abstract

          Chelerythrine (CHL), a plant alkaloid, possesses antimicrobial, anti-inflammatory, and antitumor properties. Although CHL influences several key signal transduction pathways, its ability to interact directly with nucleoprotein complex chromatin, in eukaryotic cells has so far not been looked into. Here we have demonstrated its association with hierarchically assembled chromatin components, viz. long chromatin, chromatosome, nucleosome, chromosomal DNA, and histone H3 and the consequent effect on chromatin structure. CHL was found to repress acetylation at H3K9. It is more target-specific in terms of gene expression alteration and less cytotoxic compared to its structural analog sanguinarine.

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          Author and article information

          Journal
          J. Biomol. Struct. Dyn.
          Journal of biomolecular structure & dynamics
          Informa UK Limited
          1538-0254
          0739-1102
          May 2017
          : 35
          : 7
          Affiliations
          [1 ] a Biophysics and Structural Genomics Division , Saha Institute of Nuclear Physics , Block - AF Sector-I, Bidhan Nagar, Kolkata 700064 , India.
          [2 ] b Genome Informatics Research Group , Bionivid Technology Pvt Ltd. , Bangalore 560043 , India.
          [3 ] c Division of Molecular Medicine, Centre for Translational Animal Research , Bose Institute , P 1/12, C. I. T. Road, Scheme - VIIM, Kolkata 700054 , India.
          Article
          10.1080/07391102.2016.1188154
          27494525
          122b1954-eaa9-4b5e-93ba-74e49fe05ec2
          History

          chelerythrine,cytotoxicity,dual binder,gene expression,histone H3K9 acetylation

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