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      VLA-2 and VLA-5 Cell Adhesion Molecules Expression in CD34+ Cells from Umbilical Cord Blood and from Bone Marrow

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          Abstract

          Background/Aims: Umbilical cord blood contains a large number of early hematopoietic cells with high proliferating capacity, that has been used as an alternative to bone marrow transplantation. The aim of this study is to investigate the number of two cell adhesion molecules in cord blood and in bone marrow. Methods: We investigated two integrins, named VLA-2 and VLA-5 (Very Late Appearing Antigen), expressed in the surface of CD34+ cells. The CD34+ cells, isolated with MACS CD34+ isolation kit, were labelled with the appropriate monoclonal antibodies. Results: Cell adhesion molecules showed highly expressed in both cord blood and bone marrow CD34+ cells. Conclusion: There are no significant differences between the two sources of CD34+ populations.

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          Structure and function of cell adhesion molecules.

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            Author and article information

            Journal
            BPU
            Blood Purif
            10.1159/issn.0253-5068
            Blood Purification
            S. Karger AG
            0253-5068
            1421-9735
            2002
            2002
            30 January 2002
            : 20
            : 2
            : 174-176
            Affiliations
            Departments of aMicrobiological and Gynaecological Sciences, bHaematology, cClinical Pathology, and dReproductive Medicine, University of Catania, Italy
            Article
            47005 Blood Purif 2002;20:174–176
            10.1159/000047005
            11818681
            © 2002 S. Karger AG, Basel

            Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

            Page count
            Figures: 1, Tables: 2, References: 5, Pages: 3
            Product
            Self URI (application/pdf): https://www.karger.com/Article/Pdf/47005
            Categories
            Original Paper

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