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      VLA-2 and VLA-5 Cell Adhesion Molecules Expression in CD34+ Cells from Umbilical Cord Blood and from Bone Marrow

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          Background/Aims: Umbilical cord blood contains a large number of early hematopoietic cells with high proliferating capacity, that has been used as an alternative to bone marrow transplantation. The aim of this study is to investigate the number of two cell adhesion molecules in cord blood and in bone marrow. Methods: We investigated two integrins, named VLA-2 and VLA-5 (Very Late Appearing Antigen), expressed in the surface of CD34+ cells. The CD34+ cells, isolated with MACS CD34+ isolation kit, were labelled with the appropriate monoclonal antibodies. Results: Cell adhesion molecules showed highly expressed in both cord blood and bone marrow CD34+ cells. Conclusion: There are no significant differences between the two sources of CD34+ populations.

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          Structure and function of cell adhesion molecules.


            Author and article information

            Blood Purif
            Blood Purification
            S. Karger AG
            30 January 2002
            : 20
            : 2
            : 174-176
            Departments of aMicrobiological and Gynaecological Sciences, bHaematology, cClinical Pathology, and dReproductive Medicine, University of Catania, Italy
            47005 Blood Purif 2002;20:174–176
            © 2002 S. Karger AG, Basel

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            Page count
            Figures: 1, Tables: 2, References: 5, Pages: 3
            Self URI (application/pdf): https://www.karger.com/Article/Pdf/47005
            Original Paper


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