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      Extrastriatal dopamine D2-receptor availability in social anxiety disorder.

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          Abstract

          Alterations in the dopamine system are hypothesized to influence the expression of social anxiety disorder (SAD) symptoms. However, molecular imaging studies comparing dopamine function between patients and control subjects have yielded conflicting results. Importantly, while all previous investigations focused on the striatum, findings from activation and blood flow studies indicate that prefrontal and limbic brain regions have a central role in the pathophysiology. The objective of this study was to investigate extrastriatal dopamine D2-receptor (D2-R) availability in SAD. We examined 12 SAD patients and 16 healthy controls using positron emission tomography and the high-affinity D2-R radioligand [(11)C]FLB457. Parametric images of D2-R binding potential were derived using the Logan graphical method with cerebellum as reference region. Two-tailed one-way independent ANCOVAs, with age as covariate, were used to examine differences in D2-R availability between groups using both region-based and voxel-wise analyses. The region-based analysis showed a medium effect size of higher D2-R levels in the orbitofrontal cortex (OFC) in patients, although this result did not remain significant after correction for multiple comparisons. The voxel-wise comparison revealed elevated D2-R availability in patients within OFC and right dorsolateral prefrontal cortex after correction for multiple comparisons. These preliminary results suggest that an aberrant extrastriatal dopamine system may be part of the disease mechanism in SAD.

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          Author and article information

          Journal
          Eur Neuropsychopharmacol
          European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
          Elsevier BV
          1873-7862
          0924-977X
          May 2017
          : 27
          : 5
          Affiliations
          [1 ] Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Stockholm Health Care Services, Stockholm County Council, Sweden. Electronic address: pontus.plaven-sigray@ki.se.
          [2 ] Stockholm Health Care Services, Stockholm County Council, Sweden; Division of Psychology, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
          [3 ] Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Stockholm Health Care Services, Stockholm County Council, Sweden.
          Article
          S0924-977X(17)30189-X
          10.1016/j.euroneuro.2017.03.007
          28377075
          125cf7cc-08f2-4133-af84-5ae6d0622e9e
          History

          Dopamine,Dopamine D2,Phobic disorders,Positron-Emission tomography,Prefrontal cortex,Receptors

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