Genetic variants in the renin-angiotensin system genes are associated with cardiovascular-renal-related risk factors in Mexican Americans.

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Abstract

The aim of this study is to examine whether the ACE-I/D, AGT-M235T, and AT1R-A1166C polymorphisms of the renin-angiotensin system (RAS) genes are associated with cardiovascular and renal-related risk factors in Mexican Americans. Study participants (N = 848) were genotyped by Taqman assays. Association analyses were performed by measured genotype approach. Of the phenotypes examined, the ACE-I/D, AGT-M235T, and AT1R-A1166C polymorphisms exhibited significant association with systolic blood pressure, glomerular filtration rate and body mass index, respectively. The data suggest that the polymorphisms examined in the RAS may modulate the risk factors associated with cardiovascular-renal disease.

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Journal

Journal ID (iso-abbrev): Hum. Genet.

Title: Human genetics

Publisher: Springer Nature America, Inc

ISSN (Electronic): 1432-1203

ISSN (Print): 0340-6717

Publication date (Electronic): Dec 2008

Volume: 124

Issue: 5

Affiliations

[1 ] Division of Nephrology, Department of Medicine, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA. thameem@uthscsa.edu

Article

Mid ID: NIHMS104620

DOI: 10.1007/s00439-008-0581-x

PMC ID: 2785727

PubMed ID: 18985387

SO-VID: 1261319e-a7e9-4119-861b-ccf2e75dd14b

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