12
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      The role of myofibroblasts in wound healing.

      1
      Current research in translational medicine
      Elsevier BV
      Chronic wound, Fibrosis, Hypertrophic scar, Mechanics

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The importance of proper skin wound healing becomes evident when our body's repair mechanisms fail, leading to either non-healing (chronic) wounds or excessive repair (fibrosis). Chronic wounds are a tremendous burden for patients and global healthcare systems and are on the rise due to their increasing incidence with age and diabetes. Curiously, these same risk factors also sign responsible for the development of hypertrophic scarring and organ fibrosis. Activated repair cells - myofibroblasts - are the main producers and organizers of extracellular matrix which is needed to restore tissue integrity after injury. Too many myofibroblasts working for too long cause tissue contractures that ultimately obstruct organ function. Insufficient myofibroblast activation and activities, in turn, prevents normal wound healing. This short review puts a spotlight on the myofibroblast for those who seek therapeutic targets in the context of dysregulated tissue repair. "Keep your myofibroblasts in balance" is the message.

          Related collections

          Author and article information

          Journal
          Curr Res Transl Med
          Current research in translational medicine
          Elsevier BV
          2452-3186
          2452-3186
          December 13 2016
          : 64
          : 4
          Affiliations
          [1 ] Laboratory of tissue repair and regeneration, Matrix dynamics group, faculty of dentistry, university of Toronto, 150, College Street, FitzGerald building, room 234, M5S 3E2 Toronto, Ontario, Canada. Electronic address: boris.hinz@utoronto.ca.
          Article
          S2452-3186(16)30039-3
          10.1016/j.retram.2016.09.003
          27939455
          12795706-4346-425e-ab2f-f64801a57f35
          History

          Mechanics,Chronic wound,Hypertrophic scar,Fibrosis
          Mechanics, Chronic wound, Hypertrophic scar, Fibrosis

          Comments

          Comment on this article