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      An elderly patient with hemophagocytic syndrome due to severe mycoplasma pneumonia with marked hypercytokinemia.

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          Abstract

          We present an extremely rare case of hemophagocytic syndrome (HPS) induced by fulminant Mycoplasma pneumoniae (Mp) pneumonia in an elderly adult. Erythrocytopenia and thrombocytopenia were observed in a patient with acute respiratory failure, liver dysfunction and renal failure. Mp-associated HPS was diagnosed in this case by clinical and laboratory findings, including a bone marrow aspiration specimen and serum Mp antibody titer. High serum levels of soluble interleukin-2 receptor, interleukin-6, human interleukin-10 and macrophage-colony stimulating factor were observed. Hypercytokinemia is a useful marker of disease activity and prognosis. Combined treatment with methylprednisolone and erythromycin was successful and led to a favorable outcome. Physicians should be aware of HPS as a complication in Mp infection.

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          Author and article information

          Journal
          Respiration
          Respiration; international review of thoracic diseases
          0025-7931
          0025-7931
          2002
          : 69
          : 1
          Affiliations
          [1 ] Department of Internal Medicine, National Nagasaki Hospital, Nagasaki, Japan.
          Article
          49377
          49377
          11844970
          12815326-7294-4d2b-be1b-301b1dc847de
          Copyright 2002 S. Karger AG, Basel
          History

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