Evelyn M. Covés-Datson: Role: Writing – original draftRole: Writing – review & editing
Julie Dyall: Role: Data curationRole: Formal analysisRole: InvestigationRole: Project administrationRole:
ValidationRole: VisualizationRole: Writing – original draftRole: Writing – review
& editing
Lisa Evans DeWald: Role: Data curationRole: Formal analysisRole: InvestigationRole: Project administrationRole:
VisualizationRole: Writing – original draftRole: Writing – review & editing
Steven R. King: Role: InvestigationRole: Writing – review & editing
Derek Dube: Role: InvestigationRole: Writing – review & editing
Maureen Legendre: Role: ResourcesRole: Writing – review & editing
Elizabeth Nelson: Role: Data curationRole: Formal analysisRole: InvestigationRole: ValidationRole: VisualizationRole:
Writing – original draftRole: Writing – review & editing
Kelly C. Drews: Role: Formal analysisRole: Investigation
Robin Gross: Role: Investigation
Dawn M. Gerhardt: Role: Investigation
Lisa Torzewski: Role: Investigation
Elena Postnikova: Role: Investigation
Janie Y. Liang: Role: Investigation
Bhupal Ban: Role: Resources
Jagathpala Shetty: Role: Resources
Lisa E. Hensley: Role: SupervisionRole: Writing – review & editing
Peter B. Jahrling: Role: SupervisionRole: Writing – review & editing
Gene G. Olinger Jr.: Role: ConceptualizationRole: SupervisionRole: Writing – review & editing
Judith M. White:
ORCID: http://orcid.org/0000-0002-0532-996X
Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole:
Project administrationRole: SupervisionRole: Writing – original draftRole: Writing
– review & editing
David M. Markovitz: Role: ConceptualizationRole: Funding acquisitionRole: Project administrationRole:
SupervisionRole: Writing – review & editing
Johan van Griensven: Role: Editor
Journal ID (nlm-ta): PLoS Negl Trop Dis
Journal ID (iso-abbrev): PLoS Negl Trop Dis
Journal ID (publisher-id): plos
Journal ID (pmc): plosntds
Title:
PLoS Neglected Tropical Diseases
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Print):
1935-2727
ISSN
(Electronic):
1935-2735
Publication date
(Electronic):
29
July
2019
Publication date Collection:
July
2019
Volume: 13
Issue: 7
Electronic Location Identifier: e0007595
Affiliations
[1
]
Medical Scientist Training Program, University of Michigan, Ann Arbor, Michigan, United
States of America
[2
]
Department of Microbiology & Immunology, University of Michigan, Ann Arbor, Michigan,
United States of America
[3
]
Integrated Research Facility, Division of Clinical Research, National Institute of
Allergy and Infectious Diseases, National Institutes of Health, Frederick, Maryland,
United States of America
[4
]
Division of Infectious Diseases, Department of Internal Medicine, University of Michigan,
Ann Arbor, Michigan, United States of America
[5
]
Department of Cell Biology, University of Virginia, Charlottesville, Virginia, United
States of America
[6
]
Department of Pathology, University of Virginia, Charlottesville, Virginia, United
States of America
[7
]
Antibody Engineering and Technology Core, University of Virginia, Charlottesville,
Virginia, United States of America
[8
]
Emerging Viral Pathogens Section, National Institute of Allergy and Infectious Diseases,
National Institutes of Health, Frederick, Maryland, United States of America
[9
]
Department of Microbiology, University of Virginia, Charlottesville, Virginia, United
States of America
[10
]
Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, Michigan,
United States of America
[11
]
Graduate Program in Immunology, University of Michigan, Ann Arbor, Michigan, United
States of America
[12
]
Cancer Biology Program, University of Michigan, Ann Arbor, Michigan, United States
of America
Institute of Tropical Medicine, BELGIUM
Author notes
I have read the journal's policy and the authors of this manuscript have the following
competing interests: DMM is an inventor on a patent for H84T BanLec. He is also founder
of Virule, a company that aims to commercialize H84T.
[¤a]
Current address: Emergent BioSolutions, Gaithersburg, Maryland, United States of America
[¤b]
Current address: University of Saint Joseph, West Hartford, Connecticut, United States
of America
[¤c]
Current address: Bioqual, Inc., Rockville, Maryland, United States of America
[¤d]
Current address: Indiana Biosciences Research Institute, Indianapolis, Indiana, United
States of America
[¤e]
Current address: Department of Biomedical Engineering, University of Virginia, Charlottesville,
Virginia, United States of America
[¤f]
Current address: MRIGlobal-Global Health Surveillance and Diagnostics, Gaithersburg,
MD, United States of America
Author information
Article
Publisher ID:
PNTD-D-18-02019
DOI: 10.1371/journal.pntd.0007595
PMC ID: 6687191
PubMed ID: 31356611
SO-VID: 128c8b1b-d9ba-402e-9a6e-13d4c06211ec
License:
This is an open access article, free of all copyright, and may be freely reproduced,
distributed, transmitted, modified, built upon, or otherwise used by anyone for any
lawful purpose. The work is made available under the
Creative Commons CC0 public domain dedication.
Funded by: funder-id http://dx.doi.org/10.13039/100000774, Defense Threat Reduction Agency;
Award ID: HDTRA1-15-0067
Award Recipient
:
David M. Markovitz
Funded by: funder-id http://dx.doi.org/10.13039/100000060, National Institute of Allergy and Infectious Diseases;
Award ID: 1RO1AI114776
Award Recipient
:
ORCID: http://orcid.org/0000-0002-0532-996X
Judith M. White
Funded by: funder-id http://dx.doi.org/10.13039/100000060, National Institute of Allergy and Infectious Diseases;
Award ID: 1F31AI136615-01
Award Recipient
:
Evelyn M. Covés-Datson
Funded by: funder-id http://dx.doi.org/10.13039/100000002, National Institutes of Health;
Award ID: T32 GM07863
Award Recipient
:
Evelyn M. Covés-Datson
Funded by: funder-id http://dx.doi.org/10.13039/100000002, National Institutes of Health;
Award ID: T32 AI007528
Award Recipient
:
Evelyn M. Covés-Datson
This work was supported by the Division of Intramural Research of the National Institute
of Allergy and Infectious Diseases (NIAID), Integrated Research Facility (NIAID, Division
of Clinical Research), and Battelle Memorial Institute’s prime contract with the NIAID
(Contract # HHSN272200700016I). RG, DMG, JYL, and LED performed this work as employees
of Battelle Memorial Institute (BMI). Subcontractors to BMI who performed this work
are JD and EP as employees of Tunnell Consulting, Inc., LT as an employee of Charles
River, and GGO Jr as an employee of MRIGlobal. This work was also supported by grants
to DMM from the Defense Threat Reduction Agency (HDTRA1-15-0067;
http://www.dtra.mil) and to JMW from the NIAID (1RO1AI114776;
https://www.niaid.nih.gov). EMC-D was supported by National Institutes of Health training grants to the University
of Michigan Medical Scientist Training Program (T32 GM07863) and Molecular Mechanisms
of Microbial Pathogenesis (T32 AI007528), as well as by a National Research Service
Award (1F31AI136615-01) from the NIAID. The funders had no role in study design, data
collection and analysis, decision to publish, or preparation of the manuscript.
Subject:
Research Article
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
RNA viruses
Subject:
Filoviruses
Subject:
Ebola Virus
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Medical Microbiology
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Hemorrhagic Fever Viruses
Subject:
Ebola Virus
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Pathogens
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Hemorrhagic Fever Viruses
Subject:
Ebola Virus
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral Pathogens
Subject:
Hemorrhagic Fever Viruses
Subject:
Ebola Virus
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Hemorrhagic Fever Viruses
Subject:
Ebola Virus
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Lectins
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Virology
Subject:
Viral Replication
Subject:
Biology and Life Sciences
Subject:
Developmental Biology
Subject:
Life Cycles
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
RNA viruses
Subject:
Orthomyxoviruses
Subject:
Influenza viruses
Subject:
Influenza A virus
Subject:
Biology and life sciences
Subject:
Microbiology
Subject:
Medical microbiology
Subject:
Microbial pathogens
Subject:
Viral pathogens
Subject:
Orthomyxoviruses
Subject:
Influenza viruses
Subject:
Influenza A virus
Subject:
Medicine and health sciences
Subject:
Pathology and laboratory medicine
Subject:
Pathogens
Subject:
Microbial pathogens
Subject:
Viral pathogens
Subject:
Orthomyxoviruses
Subject:
Influenza viruses
Subject:
Influenza A virus
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral pathogens
Subject:
Orthomyxoviruses
Subject:
Influenza viruses
Subject:
Influenza A virus
Subject:
Research and Analysis Methods
Subject:
Animal Studies
Subject:
Experimental Organism Systems
Subject:
Model Organisms
Subject:
Mouse Models
Subject:
Research and Analysis Methods
Subject:
Model Organisms
Subject:
Mouse Models
Subject:
Research and Analysis Methods
Subject:
Animal Studies
Subject:
Experimental Organism Systems
Subject:
Animal Models
Subject:
Mouse Models
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Medical Microbiology
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Immunodeficiency Viruses
Subject:
HIV
Subject:
HIV-1
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Pathogens
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Immunodeficiency Viruses
Subject:
HIV
Subject:
HIV-1
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral Pathogens
Subject:
Immunodeficiency Viruses
Subject:
HIV
Subject:
HIV-1
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Immunodeficiency Viruses
Subject:
HIV
Subject:
HIV-1
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
RNA viruses
Subject:
Retroviruses
Subject:
Lentivirus
Subject:
HIV
Subject:
HIV-1
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Medical Microbiology
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Retroviruses
Subject:
Lentivirus
Subject:
HIV
Subject:
HIV-1
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Pathogens
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Retroviruses
Subject:
Lentivirus
Subject:
HIV
Subject:
HIV-1
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral Pathogens
Subject:
Retroviruses
Subject:
Lentivirus
Subject:
HIV
Subject:
HIV-1
Subject:
Medicine and Health Sciences
Subject:
Tropical Diseases
Subject:
Neglected Tropical Diseases
Subject:
Viral Hemorrhagic Fevers
Subject:
Ebola Hemorrhagic Fever
Subject:
Medicine and Health Sciences
Subject:
Infectious Diseases
Subject:
Viral Diseases
Subject:
Viral Hemorrhagic Fevers
Subject:
Ebola Hemorrhagic Fever
