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      Introns and the origin of nucleus-cytosol compartmentalization.

      Nature

      Biological Evolution, Cell Compartmentation, physiology, Cell Nucleus, genetics, metabolism, Chromosomes, Cytosol, Eukaryotic Cells, cytology, Introns, Mitochondria, Models, Biological, Nuclear Envelope, Protein Biosynthesis, RNA, Ribosomes

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          Abstract

          The origin of the eukaryotic nucleus marked a seminal evolutionary transition. We propose that the nuclear envelope's incipient function was to allow mRNA splicing, which is slow, to go to completion so that translation, which is fast, would occur only on mRNA with intact reading frames. The rapid, fortuitous spread of introns following the origin of mitochondria is adduced as the selective pressure that forged nucleus-cytosol compartmentalization.

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          Journal
          16511485
          10.1038/nature04531

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