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Superior overall survival of patients with myeloma achieving very good partial response or better to initial treatment with bortezomib, pegylated liposomal doxorubicin, and dexamethasone, predicted after two cycles by a free light chain- and M-protein-based model: extended follow-up of a phase II trial.

Leukemia & Lymphoma

Treatment Outcome, Antineoplastic Combined Chemotherapy Protocols, Survival Analysis, administration & dosage, Pyrazines, Prognosis, Polyethylene Glycols, metabolism, Myeloma Proteins, mortality, drug therapy, diagnosis, Multiple Myeloma, Models, Statistical, blood, Immunoglobulin Light Chains, Humans, Follow-Up Studies, analogs & derivatives, Doxorubicin, Dexamethasone, Boronic Acids, therapeutic use

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      Abstract

      In myeloma, achievement of very good partial response (VGPR) post-transplant is associated with prolonged overall (OS) and progression-free survival (PFS). In this study of bortezomib, pegylated liposomal doxorubicin, and dexamethasone (VDD) in 40 patients with newly diagnosed myeloma (median follow-up 45.1 months), 2-/4-year OS estimates were 95.7%/86.5% versus 82.4%/58.2% for patients achieving ≥VGPR versus 

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      Journal
      10.3109/10428194.2011.567316
      21699382

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