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      Reduced PTEN protein expression and its prognostic implications in canine and feline mammary tumors.

      1 , , , ,

      Veterinary pathology

      SAGE Publications

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          Abstract

          Phosphatase and tensin homolog (PTEN) belongs to the group of gatekeeper tumor suppressor genes and is involved in multiple mechanisms leading to cellular defense against neoplastic transformation and progression. Twenty-four dogs and 17 cats were submitted to a 2-year follow-up study, and clinicopathologic features were recorded and compared with immunohistochemical PTEN staining. PTEN-negative status occurred in 33% of canine and 76% of feline mammary carcinomas. In canine mammary carcinomas, there was a significant (P < .05) correlation between loss of PTEN protein expression and simple carcinoma histotype, lymphatic vessel invasion, lymph node metastases, distant organ metastases, tumor dedifferentiation, tumor recurrence, and shorter overall survival. In feline mammary tumors, a significant correlation between loss of PTEN protein expression and lymphatic vessel invasion was found. Loss of PTEN expression could be a useful prognostic marker in canine mammary carcinomas.

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          Author and article information

          Journal
          Vet. Pathol.
          Veterinary pathology
          SAGE Publications
          1544-2217
          0300-9858
          Sep 2009
          : 46
          : 5
          Affiliations
          [1 ] Department of Animal Pathology, School of Veterinary Medicine, University of Pisa, Italy.
          Article
          vp.08-VP-0273-P-FL
          10.1354/vp.08-VP-0273-P-FL
          19429983

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