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      Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease.

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          Abstract

          Oestrogen use by postmenopausal women has many health benefits, but findings on the effect of oestrogen in Alzheimer's disease are conflicting. Oestrogen promotes the growth and survival of cholinergic neurons and could decrease cerebral amyloid deposition, both of which may delay the onset or prevent Alzheimer's disease. To investigate whether use of oestrogen during the postmenopausal period affects the risk of Alzheimer's disease, we studied 1124 elderly women who were initially free of Alzheimer's disease, Parkinson's disease, and stroke, and who were taking part in a longitudinal study of ageing and health in a New York City community.

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          Author and article information

          Journal
          Lancet
          Lancet (London, England)
          Elsevier BV
          0140-6736
          0140-6736
          Aug 17 1996
          : 348
          : 9025
          Affiliations
          [1 ] Gertrude H Serglevsky Center, Columbia University, New York, NY 10032, USA.
          Article
          S0140-6736(96)03356-9
          10.1016/S0140-6736(96)03356-9
          8709781
          12ca6396-7456-459a-bfae-b978940aaa3b
          History

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