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      Germanene-Based Theranostic Materials for Surgical Adjuvant Treatment: Inhibiting Tumor Recurrence and Wound Infection

      , , , , , , , , ,
      Matter
      Elsevier BV

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          Cancer nanomedicine: progress, challenges and opportunities

          The intrinsic limits of conventional cancer therapies prompted the development and application of various nanotechnologies for more effective and safer cancer treatment, herein referred to as cancer nanomedicine. Considerable technological success has been achieved in this field, but the main obstacles to nanomedicine becoming a
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            In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment

            Cancer recurrence after surgical resection remains a significant cause of treatment failure. Here, we have developed an in situ formed immunotherapeutic bioresponsive gel that controls both local tumour recurrence after surgery and development of distant tumours. Briefly, calcium carbonate nanoparticles pre-loaded with the anti-CD47 antibody are encapsulated in the fibrin gel and scavenge H+ in the surgical wound, allowing polarization of tumour-associated macrophages to the M1-like phenotype. The released anti-CD47 antibody blocks the 'don't eat me' signal in cancer cells, thereby increasing phagocytosis of cancer cells by macrophages. Macrophages can promote effective antigen presentation and initiate T cell mediated immune responses that control tumour growth. Our findings indicate that the immunotherapeutic fibrin gel 'awakens' the host innate and adaptive immune systems to inhibit both local tumour recurrence post surgery and potential metastatic spread.
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              Black Phosphorus Nanosheets as a Robust Delivery Platform for Cancer Theranostics.

              2D black phosphorus (BP) nanomaterials are presented as a delivery platform. The endocytosis pathways and biological activities of PEGylated BP nanosheets in cancer cells are revealed for the first time. Finally, a triple-response combined therapy strategy is achieved by PEGylated BP nanosheets, showing a promising and enhanced antitumor effect.
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                Author and article information

                Contributors
                Journal
                Matter
                Matter
                Elsevier BV
                25902385
                July 2020
                July 2020
                : 3
                : 1
                : 127-144
                Article
                10.1016/j.matt.2020.04.022
                12d35551-1b50-4b1a-ae3b-a5bc773993ff
                © 2020

                https://www.elsevier.com/tdm/userlicense/1.0/

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